Empazin M 5 mg+1000 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Patients insufficiently controlled on maximally tolerated dose of Metformin alone
- Combination with other medicinal products for the treatment of diabetes
- Renal threshold for glucose
- Increases urinary glucose excretion
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
Dosage & Administration
- Twice daily with meals
- Individualized based on effectiveness and tolerability
- Dose escalation should be gradual
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
Interaction
- Co-administration with diuretics
- Co-administration with insulin or insulin secretagogues
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that reduce Metformin clearance
- Carbonic Anhydrase Inhibitors
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis (lactic acidosis, diabetic ketoacidosis)
- Severe renal failure (GFR < 30 ml/min)
- Acute conditions altering renal function
- Diseases causing tissue hypoxia
- Hepatic impairment, acute alcohol intoxication, alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Serum lipids increased
- Volume depletion
- Urticaria
- Dysuria
- Blood creatinine increased/Glomerular filtration rate decreased
- Haematocrit increased
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity at high doses of Empagliflozin and Metformin
- Hypoglycemia not seen with high doses of Metformin
- Lactic acidosis is a medical emergency
- Treatment should be initiated as appropriate to the patient's clinical status
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children