Empazin M 12.5 mg+500 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Treatment for adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on Metformin alone
- Combination therapy for diabetes treatment
- Adjunct to Empagliflozin and Metformin separately
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
- Extended-release formulations available
- Adjust dosing based on renal function
- Not recommended for pediatric patients under 18 years of age
Interaction
- Increased urine volume and frequency of voids with diuretics
- Increased risk of hypoglycemia with insulin or insulin secretagogues
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that reduce Metformin clearance may increase accumulation
- Increased risk of lactic acidosis with carbonic anhydrase inhibitors
- Potential impact on glycemic control by various drugs
- Alcohol can potentiate the effect of Metformin on lactate metabolism
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Conditions altering renal function
- Disease causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Increased urination
- Increased serum lipids
- Potential lactic acidosis
Pregnancy & Lactation
- Risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic acidosis risk
- Hypotension risk
- Ketoacidosis assessment
- Acute kidney injury caution
- Increased risk of urinary tract infections and mycotic infections
- Hypoglycemia risk
- Vitamin B12 deficiency monitoring
- Increased LDL-C monitoring
- No conclusive evidence of macrovascular risk reduction
Overdose Effects
- No toxicity observed with high Empagliflozin doses in clinical studies
- No hypoglycemia observed with high Metformin doses
- Lactic acidosis is a medical emergency
- Treatment should be initiated based on clinical status
- Haemodialysis may be effective for Metformin removal
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children