Empazin M 12.5 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Delta pharma ltd
Also available as
Empazin m 5 mg tablet Empazin m 5 mg tablet

Indications

  • Treatment for adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on Metformin alone
  • Combination therapy for diabetes treatment
  • Adjunct to Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
  • Extended-release formulations available
  • Adjust dosing based on renal function
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Increased urine volume and frequency of voids with diuretics
  • Increased risk of hypoglycemia with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance may increase accumulation
  • Increased risk of lactic acidosis with carbonic anhydrase inhibitors
  • Potential impact on glycemic control by various drugs
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Conditions altering renal function
  • Disease causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection
  • Increased urination
  • Increased serum lipids
  • Potential lactic acidosis

Pregnancy & Lactation

  • Risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic acidosis risk
  • Hypotension risk
  • Ketoacidosis assessment
  • Acute kidney injury caution
  • Increased risk of urinary tract infections and mycotic infections
  • Hypoglycemia risk
  • Vitamin B12 deficiency monitoring
  • Increased LDL-C monitoring
  • No conclusive evidence of macrovascular risk reduction

Overdose Effects

  • No toxicity observed with high Empagliflozin doses in clinical studies
  • No hypoglycemia observed with high Metformin doses
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated based on clinical status
  • Haemodialysis may be effective for Metformin removal

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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