Lopera 1 mg/5 ml (Oral Solution)

Title

• Lopera Capsule

Categories

• Medicine
• Gastrointestinal Health
• Pharmacology
• Anti-Diarrhoeal
• Medical
• Health

Description

• Loperamide Hydrochloride inhibits peristaltic activity
• Orally administered capsule
• Pharmacokinetics: Absorption, metabolism, elimination
• Dosage guidelines for adults and children
• Contraindications for use
• Common side effects
• Safety in pregnancy and lactation
• Precautions for hepatic disturbances
• Storage recommendations

Dimensions

• Standard capsule size

Color Options

• None

Functions

• Inhibits peristaltic activity
• Binds to opiate receptors in the gut wall
• Reduces propulsive peristalsis
• Increases intestinal transit time
• Increases tone of anal sphincter
• Inhibits electrolyte and fluid secretion in the intestine

Materials

• Loperamide Hydrochloride
• Inactive ingredients of the capsule

Technical Specifications

• Oral administration
• Absorption rate of more than 65%
• Peak serum levels at 2-3 µgm/litre after 4 hours
• Extensive presystemic first-pass metabolism
• Minimal systemic circulation due to high affinity for gut wall
• Excretion in urine and bile

Design Elements

• Capsule form

Usability Features

• Dosage instructions for acute and chronic diarrhea
• Storage instructions
• Precautions for use in pregnancy and lactation
• Precautions for hepatic disturbances

Safety Features

• Contraindications for hypersensitivity
• Caution in patients who must avoid constipation
• Caution in severe hepatic disturbances

Dosage Guidelines

• Initial adult dosage: 2 capsules followed by 1 capsule after each loose stool
• Usual adult dosage: 3-4 capsules/day, maximum 8 capsules/day
• Children (9-12 years): 1 capsule after each loose stool, maximum 6 capsules/day
• Children (5-9 years): 1 capsule 4 times daily, maximum 4 capsules/day
• Chronic diarrhea: Adults 2-4 capsules daily, Children 1-2 capsules daily

Side Effects

• Abdominal pain
• Dry mouth
• Dizziness
• Fatigue
• Skin rashes

Contraindications

• Hypersensitivity to the drug
• Patients who must avoid constipation
• Acute dysentery with blood in stool and elevated body temperature

Pregnancy & Lactation

• Safety not established in human pregnancy
• Not advisable to administer in pregnancy
• Caution in nursing mothers

Precautions & Warnings

• Use with caution in severe hepatic disturbance

Overdose Effects

• Constipation
• CNS depression
• Nausea

Therapeutic Class

• Anti-diarrhoeal
• Anti-motility drugs

Storage Conditions

• Keep out of reach of children
• Store in cool, dry place protected from light

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