Jardimet XR 5 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Jardimet 5 mg tablet Jardimet xr 10 mg tablet Jardimet xr 25 mg tablet

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Indications

  • Treatment of type 2 diabetes mellitus in adults as adjunct to diet and exercise
  • Adjunct therapy in patients insufficiently controlled on maximally tolerated dose of Metformin alone
  • Adjunct therapy in combination with other medicinal products for diabetes treatment
  • Adjunct therapy in patients already being treated with the combination of Empagliflozin and Metformin as separate tablets

Pharmacology

  • Empagliflozin inhibits Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
  • Lowering of basal and postprandial plasma glucose
  • Reduction of renal reabsorption of filtered glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Twice daily administration with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
  • Recommended individualized starting dose based on patient's drug regimen
  • Dose adjustment for renal impaired patients
  • Extended-release formulations available
  • Dosing adjustment for extended-release formulations
  • Pediatric patients under 18 years of age are not recommended

Interaction

  • Co-administration with diuretics increases urine volume and frequency of voids
  • Co-administration with insulin or insulin secretagogues increases the risk for hypoglycemia
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance may increase the accumulation of Metformin
  • Carbonic Anhydrase Inhibitors may increase risk of lactic acidosis
  • Drugs affecting glycemic control need careful monitoring
  • Alcohol intake can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis (lactic acidosis, diabetic ketoacidosis)
  • Severe renal failure
  • Conditions altering renal function such as dehydration, severe infection, shock
  • Disease causing tissue hypoxia such as heart failure, respiratory failure, recent myocardial infarction, shock
  • Hepatic impairment, acute alcohol intoxication, alcoholism

Side Effects

  • Most common adverse reactions associated with Empagliflozin include urinary tract infection and female genital mycotic infections
  • Most common adverse reactions associated with Metformin include diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache
  • Hypoglycemia, Gastrointestinal symptoms, Vaginal moniliasis, vulvovaginitis, balanitis, urinary tract infection, thirst, taste disturbance, pruritus, rash, Increased urination, serum lipids increased, Volume depletion, urticaria, dysuria, blood creatinine increased/Glomerular filtration rate decreased, Haematocrit increased, Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus especially during the second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Risk of Lactic Acidosis
  • Hypotension in certain patient groups
  • Risk of Ketoacidosis
  • Acute kidney injury and impairment in renal function
  • Increased risk for urosepsis, pyelonephritis, Fournier's gangrene, and genital mycotic infections
  • Risk of Hypoglycemia
  • Potential for Vitamin B12 Deficiency
  • Monitoring and treatment for increased LDL-C
  • No conclusive evidence of macrovascular risk reduction

Overdose Effects

  • No toxicity observed at high single doses of Empagliflozin
  • Lactic acidosis reported with high Metformin doses
  • Medical emergency in case of lactic acidosis
  • Treatment should be based on patient's clinical status
  • Haemodialysis for removal of lactate and Metformin

Storage Conditions

  • Store below 30°C temperature
  • Protect from light and moisture
  • Keep out of the reach of children

Related Brands