Jardimet XR 10 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Jardimet 5 mg tablet Jardimet xr 5 mg tablet Jardimet xr 25 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • In patients insufficiently controlled on Metformin alone
  • In combination with other medicinal products for diabetes
  • In patients already being treated with Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness
  • Take twice daily with meals
  • Dose escalation should be gradual
  • Maximum daily dose of Metformin Hydrochloride is 2000 mg
  • Maximum daily dose of Empagliflozin is 25 mg

Interaction

  • Diuretics may enhance potential for volume depletion
  • Co-administration with insulin increases risk for hypoglycemia
  • Monitoring glycemic control with urine glucose tests is not recommended
  • Drugs that reduce Metformin clearance may increase accumulation of Metformin
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Acute conditions altering renal function
  • Diseases causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Hypoglycemia
  • Vaginal moniliasis
  • Increased urination
  • Volume depletion

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended when breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity observed in controlled clinical studies
  • Hypoglycemia not observed with Metformin doses up to 85 g
  • Lactic acidosis is a medical emergency

Therapeutic Class

Oral hypoglycemic preparations

Storage Conditions

Keep below 30°C, protected from light & moisture, keep out of the reach of children

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