Duoliv 10 mg (Tablet)
Unit Price: ৳ 55.00 (1 x 10: ৳ 550.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of primary biliary cholangitis in adult patients
- Indicated with or without compensated cirrhosis
- Indicated for patients intolerant to UDCA
Pharmacology
- Mechanism of action as FXR agonist
- Regulator of bile acid, inflammatory, and metabolic pathways
- Reduction in intracellular hepatocyte concentrations of bile acids
Dosage & Administration
- First 3 months dosage of 5 mg daily
- Maximum dosage of 10 mg daily
- Monitoring for biochemical response and tolerability
Interactions
- Interaction with bile acid binding resins
- Potential interaction with warfarin
- Recommendation for therapeutic monitoring of CYP1A2 substrates
Contraindications
- Contraindicated in decompensated cirrhosis patients
- Contraindicated in patients with evidence of portal hypertension
- Contraindicated in patients with complete biliary obstruction
Side Effects
- Common side effects include pruritus, fatigue, and stomach pain
- Other common side effects include rash, joint pain, and dizziness
- Potential adverse effects on thyroid function and lipid levels
Pregnancy & Lactation
- Limited available human data on use during pregnancy
- No information on the effects on the breastfed infant
- Consideration of clinical need for lactating mothers
Precautions & Warnings
- Risks of hepatic decompensation and failure in cirrhosis patients
- Management strategies for severe pruritus
- Monitoring for reduction in HDL-C levels
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Consideration for geriatric use
- Risks of hepatic decompensation in patients with hepatic impairment
Overdose Effects
- Dose-dependent increase in hepatic adverse reactions
- Serious adverse reactions in patients with decompensated cirrhosis
- Recommendation for careful observation and supportive care
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Storage below 30°C in a dry place
- Protection from light
- Keep out of children’s reach