EmpaMet 12.5 mg+500 mg (Tablet)

Unit Price: ৳ 28.00 (3 x 10: ৳ 840.00)
Strip Price: ৳ 280.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 5 mg tablet Empamet xr 5 mg tablet Empamet xr 10 mg tablet Empamet xr 25 mg tablet Empamet 5 mg tablet Empamet 125 mg tablet Empamet 125 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • For patients insufficiently controlled on Metformin alone
  • For patients in combination therapy for diabetes
  • For patients already on Empagliflozin and Metformin
  • Once daily dosing
  • Extended-release formulation available
  • Not for pediatric patients under 18

Pharmacology

  • Empagliflozin: SGLT2 inhibitor
  • Metformin Hydrochloride: Biguanide antihyperglycemic drug
  • Mechanism of action
  • Effects on glucose reabsorption
  • Effects on renal threshold for glucose
  • Improvement in insulin sensitivity

Dosage & Administration

  • Individualized dosing based on effectiveness
  • Twice daily with meals
  • Gradual dose escalation
  • Maximum recommended daily doses
  • Starting dose based on current regimen
  • Renal impaired patient assessment
  • Dosing adjustments

Interactions

  • Diuretics interaction
  • Insulin and secretagogues interaction
  • Monitoring glucose control
  • Drugs affecting Metformin clearance
  • Carbonic anhydrase inhibitors interaction
  • Alcohol interaction

Contraindications

  • Hypersensitivity reactions
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions affecting renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Alcohol intoxication

Side Effects

  • Urinary tract infection
  • Genital mycotic infections
  • Gastrointestinal symptoms
  • Hypoglycemia
  • Volume depletion
  • Increased urination
  • Diarrhea
  • Nausea/vomiting
  • Headache

Pregnancy & Lactation

  • Risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis risk
  • Hypotension
  • Ketoacidosis assessment
  • Acute kidney injury considerations
  • Urosepsis and genital infections
  • Hypoglycemia risk
  • Vitamin B12 deficiency monitoring
  • Increased LDL-C monitoring

Overdose Effects

  • Empagliflozin toxicity studies
  • Metformin overdose effects
  • Lactic acidosis treatment
  • Appropriate overdose treatment
  • Haemodialysis for Metformin removal

Therapeutic Class

  • Oral hypoglycemic preparations
  • Combination therapy

Storage Conditions

  • Temperature control
  • Protection from light and moisture
  • Child-proof storage

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