EmpaMet 5 mg+850 mg (Tablet)

Unit Price: ৳ 22.00 (4 x 8: ৳ 704.00)
Strip Price: ৳ 176.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 125 mg tablet Empamet xr 5 mg tablet Empamet xr 10 mg tablet Empamet xr 25 mg tablet Empamet 5 mg tablet Empamet 125 mg tablet Empamet 125 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on Metformin alone
  • Combination with other medicinal products for diabetes
  • Usable for patients on Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Increases peripheral glucose uptake and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Take twice daily with meals
  • Maximum recommended daily doses: 2000 mg Metformin, 25 mg Empagliflozin
  • Extended-release formulations available
  • Dosing adjustment for renal impaired patients
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Increased urine volume and frequency with diuretics
  • Increased risk of hypoglycemia with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose test not recommended
  • Drugs that reduce Metformin clearance may increase accumulation
  • Carbonic Anhydrase Inhibitors may increase risk of lactic acidosis
  • Other drugs affecting glycemic control

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Severe renal failure (GFR < 30 ml/min)
  • Acute conditions altering renal function
  • Diseases causing tissue hypoxia
  • Hepatic impairment, acute alcohol intoxication, alcoholism

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Thirst
  • Taste disturbance
  • Pruritus (generalised)
  • Rash
  • Increased urination
  • Increased serum lipids
  • Volume depletion
  • Urticaria
  • Dysuria
  • Increased blood creatinine/Glomerular filtration rate
  • Rare: Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia risk
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Lack of evidence for macrovascular risk reduction

Overdose Effects

  • No toxicity observed at high single or multiple doses
  • Lactic acidosis risk with high Metformin doses
  • Hypoglycemia not seen with Metformin overdoses
  • Medical emergency requiring hospital treatment
  • Haemodialysis for lactate and Metformin removal

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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