EmpaMet XR 5 mg+1000 mg (Tablet (Extended Release))
Unit Price: ৳ 25.00 (2 x 8: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Adjunct treatment for type 2 diabetes mellitus
- Insufficiently controlled on maximally tolerated dose of Metformin alone
- Combination therapy for diabetes treatment
- Use in combination with Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Take twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Max recommended daily doses: Metformin 2000 mg, Empagliflozin 25 mg
- Extended-release formulations available
- Renal impaired patient assessment required
- Safety and effectiveness not established in pediatric patients
Interaction
- Co-administration with diuretics can increase urine volume
- Co-administration with insulin increases risk for hypoglycemia
- Monitoring glycemic control with urine tests not recommended
- Drugs reducing Metformin clearance may increase accumulation
- Risk of lactic acidosis with carbonic anhydrase inhibitors
- Certain drugs may affect glycemic control
- Alcohol can potentiate the effect of Metformin on lactate metabolism
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure (GFR <30 ml/min)
- Conditions altering renal function
- Tissue hypoxia-related diseases
- Hepatic impairment, acute alcohol intoxication, alcoholism
Side Effects
- Common adverse reactions associated with Empagliflozin and Metformin
- Most common adverse reactions for Empagliflozin: urinary tract infection, female genital mycotic infections
- Most common adverse reactions for Metformin: diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache
Pregnancy & Lactation
- Potential risk to fetus, especially in second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis risk
- Hypotension risk
- Ketoacidosis risk
- Acute kidney injury & impairment in renal function
- Increased risk for urinary tract infections
- Hypoglycemia risk
- Vitamin B12 deficiency risk
- Increased LDL-C risk
- No clinical studies for macrovascular risk reduction
Overdose Effects
- Empagliflozin overdose studies in healthy volunteers and patients with type 2 diabetes
- No hypoglycemia seen with Metformin overdose
- Lactic acidosis treatment in case of overdose
- Haemodialysis for removal of lactate and Metformin
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children