EmpaMet XR 5 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 25.00 (2 x 8: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 125 mg tablet Empamet 5 mg tablet Empamet xr 10 mg tablet Empamet xr 25 mg tablet Empamet 5 mg tablet Empamet 125 mg tablet Empamet 125 mg tablet

Indications

  • Adjunct treatment for type 2 diabetes mellitus
  • Insufficiently controlled on maximally tolerated dose of Metformin alone
  • Combination therapy for diabetes treatment
  • Use in combination with Empagliflozin and Metformin as separate tablets

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Take twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Max recommended daily doses: Metformin 2000 mg, Empagliflozin 25 mg
  • Extended-release formulations available
  • Renal impaired patient assessment required
  • Safety and effectiveness not established in pediatric patients

Interaction

  • Co-administration with diuretics can increase urine volume
  • Co-administration with insulin increases risk for hypoglycemia
  • Monitoring glycemic control with urine tests not recommended
  • Drugs reducing Metformin clearance may increase accumulation
  • Risk of lactic acidosis with carbonic anhydrase inhibitors
  • Certain drugs may affect glycemic control
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure (GFR <30 ml/min)
  • Conditions altering renal function
  • Tissue hypoxia-related diseases
  • Hepatic impairment, acute alcohol intoxication, alcoholism

Side Effects

  • Common adverse reactions associated with Empagliflozin and Metformin
  • Most common adverse reactions for Empagliflozin: urinary tract infection, female genital mycotic infections
  • Most common adverse reactions for Metformin: diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache

Pregnancy & Lactation

  • Potential risk to fetus, especially in second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis risk
  • Hypotension risk
  • Ketoacidosis risk
  • Acute kidney injury & impairment in renal function
  • Increased risk for urinary tract infections
  • Hypoglycemia risk
  • Vitamin B12 deficiency risk
  • Increased LDL-C risk
  • No clinical studies for macrovascular risk reduction

Overdose Effects

  • Empagliflozin overdose studies in healthy volunteers and patients with type 2 diabetes
  • No hypoglycemia seen with Metformin overdose
  • Lactic acidosis treatment in case of overdose
  • Haemodialysis for removal of lactate and Metformin

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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