EmpaMet XR 10 mg+1000 mg (Tablet (Extended Release))
Unit Price: ৳ 35.00 (2 x 8: ৳ 560.00)
Strip Price: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- In patients insufficiently controlled on Metformin alone
- In combination with other medicinal products for diabetes
- In patients already being treated with Empagliflozin and Metformin separately
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Take twice daily with meals
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
- Maximum recommended daily dose of Empagliflozin is 25 mg
- Extended-release formulations available
- Dosage adjustment for renal impaired patients
- Not recommended for pediatric patients under 18 years of age
Interaction
- Diuretics - increased urine volume and frequency of voids
- Insulin or Insulin Secretagogues - increased risk for hypoglycemia
- Positive Urine Glucose Test - not recommended
- Drugs that Reduce Metformin Clearance - may increase the accumulation of Metformin
- Carbonic Anhydrase Inhibitors - may increase risk of lactic acidosis
- Drugs Affecting Glycemic Control - may affect glycemic control
- Alcohol - can potentiate the effect of Metformin on lactate metabolism
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis)
- Diabetic pre-coma
- Severe renal failure (GFR <30 ml/min)
- Acute conditions with the potential to alter renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Serum lipids increased
- Volume depletion
- Urticaria
- Dysuria
- Blood creatinine increased
- Haematocrit increased
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No observed toxicity at high doses of Empagliflozin
- Hypoglycemia not seen with Metformin doses up to 85g
- Lactic acidosis is a medical emergency
- Treatment should be initiated as appropriate
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children