EmpaMet XR 10 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 35.00 (2 x 8: ৳ 560.00)
Strip Price: ৳ 280.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 125 mg tablet Empamet 5 mg tablet Empamet xr 5 mg tablet Empamet xr 25 mg tablet Empamet 5 mg tablet Empamet 125 mg tablet Empamet 125 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • In patients insufficiently controlled on Metformin alone
  • In combination with other medicinal products for diabetes
  • In patients already being treated with Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Take twice daily with meals
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
  • Maximum recommended daily dose of Empagliflozin is 25 mg
  • Extended-release formulations available
  • Dosage adjustment for renal impaired patients
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Diuretics - increased urine volume and frequency of voids
  • Insulin or Insulin Secretagogues - increased risk for hypoglycemia
  • Positive Urine Glucose Test - not recommended
  • Drugs that Reduce Metformin Clearance - may increase the accumulation of Metformin
  • Carbonic Anhydrase Inhibitors - may increase risk of lactic acidosis
  • Drugs Affecting Glycemic Control - may affect glycemic control
  • Alcohol - can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis)
  • Diabetic pre-coma
  • Severe renal failure (GFR <30 ml/min)
  • Acute conditions with the potential to alter renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication
  • Alcoholism

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection
  • Thirst
  • Taste disturbance
  • Pruritus
  • Rash
  • Increased urination
  • Serum lipids increased
  • Volume depletion
  • Urticaria
  • Dysuria
  • Blood creatinine increased
  • Haematocrit increased
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No observed toxicity at high doses of Empagliflozin
  • Hypoglycemia not seen with Metformin doses up to 85g
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated as appropriate

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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