EmpaMet XR 25 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 55.00 (2 x 8: ৳ 880.00)
Strip Price: ৳ 440.00

Medicine Details

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on maximally tolerated dose of Metformin alone
  • Combination with other medicinal products for diabetes treatment
  • Treatment of patients already being treated with Empagliflozin and Metformin as separate tablets

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
  • Maximum recommended daily dose of Empagliflozin is 25 mg
  • Recommended individualized starting dose based on current drug regimen
  • Extended-release formulations available

Interaction

  • Co-administration of diuretics
  • Co-administration of insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance
  • Carbonic Anhydrase Inhibitors
  • Drugs affecting glycemic control
  • Alcohol intake

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication
  • Alcoholism

Side Effects

  • Most common adverse reactions associated with Empagliflozin and Metformin
  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia (when used with sulphonylurea or insulin)

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended when breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity observed at high single and multiple doses in clinical studies
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated as appropriate
  • Most effective method for removal is haemodialysis

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of reach of children

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