EmpaMet XR 25 mg+1000 mg (Tablet (Extended Release))
Unit Price: ৳ 55.00 (2 x 8: ৳ 880.00)
Strip Price: ৳ 440.00
Medicine Details
Category | Details |
---|---|
Generic | Empagliflozin metformin hydrochloride |
Company | Nipro jmi pharma ltd |
Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on maximally tolerated dose of Metformin alone
- Combination with other medicinal products for diabetes treatment
- Treatment of patients already being treated with Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
- Maximum recommended daily dose of Empagliflozin is 25 mg
- Recommended individualized starting dose based on current drug regimen
- Extended-release formulations available
Interaction
- Co-administration of diuretics
- Co-administration of insulin or insulin secretagogues
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that reduce Metformin clearance
- Carbonic Anhydrase Inhibitors
- Drugs affecting glycemic control
- Alcohol intake
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Most common adverse reactions associated with Empagliflozin and Metformin
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia (when used with sulphonylurea or insulin)
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended when breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity observed at high single and multiple doses in clinical studies
- Lactic acidosis is a medical emergency
- Treatment should be initiated as appropriate
- Most effective method for removal is haemodialysis
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of reach of children
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