EmpaMet 5 mg+1000 mg (Tablet)

Unit Price: ৳ 23.00 (4 x 8: ৳ 736.00)
Strip Price: ৳ 184.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 125 mg tablet Empamet 5 mg tablet Empamet xr 5 mg tablet Empamet xr 10 mg tablet Empamet xr 25 mg tablet Empamet 125 mg tablet Empamet 125 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Patients insufficiently controlled on Metformin alone
  • Combination with other diabetes medicinal products
  • Patients already being treated with Empagliflozin and Metformin

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Twice daily with meals
  • Dose escalation should be gradual
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
  • Maximum recommended daily dose of Empagliflozin is 25 mg
  • Extended-release formulations available
  • Individualized starting dose based on current drug regimen
  • Renal function assessment before initiating
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Co-administration with diuretics
  • Co-administration with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance
  • Risk of lactic acidosis with carbonic anhydrase inhibitors
  • Impact of various drugs on glycemic control
  • Potentiation of Metformin effect by alcohol

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection
  • Thirst
  • Taste disturbance
  • Pruritus
  • Rash
  • Increased urination
  • Increased serum lipids
  • Volume depletion
  • Urticaria
  • Dysuria
  • Increased blood creatinine/Glomerular filtration rate
  • Increased haematocrit
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus in second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Unclear evidence of macrovascular risk reduction

Overdose Effects

  • No toxicity at high doses of Empagliflozin
  • Lactic acidosis in Metformin overdose
  • Hypoglycemia has not been seen with Metformin doses up to 85 g
  • In cases of overdose, treatment must be initiated based on clinical status

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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