EmpaMet 12.5 mg+850 mg (Tablet)
Unit Price: ৳ 30.00 (4 x 8: ৳ 960.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- treatment of adults with type 2 diabetes mellitus
- adjunct to diet and exercise
- insufficiently controlled on maximally tolerated dose of Metformin alone
- combination with other medicinal products for diabetes
- patients with volume depletion
- patients with renal impairment
- pediatric patients under 18 years of age
Pharmacology
- inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- reduces renal reabsorption of filtered glucose
- increases urinary glucose excretion
- lowers basal and postprandial plasma glucose
- does not produce hypoglycemia
- decreases hepatic glucose production
- improves insulin sensitivity
Dosage & Administration
- individualized based on effectiveness and tolerability
- take twice daily with meals
- dose escalation should be gradual
- maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
- extended-release formulations available
- renal impaired patient assessment before initiating
Interaction
- with diuretics
- with insulin or insulin secretagogues
- avoid monitoring glycemic control with urine glucose tests
- drugs that reduce Metformin clearance
- carbonic anhydrase inhibitors interaction
- alcohol interaction
Contraindications
- hypersensitivity to Empagliflozin and Metformin
- acute metabolic acidosis
- severe renal failure
- acute conditions altering renal function
- diseases causing tissue hypoxia
- hepatic impairment
- acute alcohol intoxication
Side Effects
- urinary tract infection
- genital mycotic infections
- diarrhea
- nausea/vomiting
- flatulence
- abdominal discomfort
- hypoglycemia
- vaginal moniliasis
- volume depletion
- urticaria
- dysuria
Pregnancy & Lactation
- risks during second and third trimesters
- not recommended during breastfeeding
Precautions & Warnings
- lactic acidosis
- hypotension
- ketoacidosis
- acute kidney injury & impairment in renal function
- urosepsis, pyelonephritis, Fournier’s gangrene & genital mycotic infections
- hypoglycemia
- Vitamin B12 Deficiency
- increased LDL-C
- macrovascular outcomes
Overdose Effects
- no toxicity observed in controlled clinical studies
- lactic acidosis in case of Metformin overdose
- treatment should be initiated as appropriate
Therapeutic Class
Combination Oral hypoglycemic preparations
Storage Conditions
Keep below 30°C temperature, protected from light & moisture, Keep out of the reach of children