EmpaMet 12.5 mg+850 mg (Tablet)

Unit Price: ৳ 30.00 (4 x 8: ৳ 960.00)
Strip Price: ৳ 240.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Nipro jmi pharma ltd
Also available as
Empamet 5 mg tablet Empamet 125 mg tablet Empamet 5 mg tablet Empamet xr 5 mg tablet Empamet xr 10 mg tablet Empamet xr 25 mg tablet Empamet 5 mg tablet Empamet 125 mg tablet

Indications

  • treatment of adults with type 2 diabetes mellitus
  • adjunct to diet and exercise
  • insufficiently controlled on maximally tolerated dose of Metformin alone
  • combination with other medicinal products for diabetes
  • patients with volume depletion
  • patients with renal impairment
  • pediatric patients under 18 years of age

Pharmacology

  • inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • reduces renal reabsorption of filtered glucose
  • increases urinary glucose excretion
  • lowers basal and postprandial plasma glucose
  • does not produce hypoglycemia
  • decreases hepatic glucose production
  • improves insulin sensitivity

Dosage & Administration

  • individualized based on effectiveness and tolerability
  • take twice daily with meals
  • dose escalation should be gradual
  • maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
  • extended-release formulations available
  • renal impaired patient assessment before initiating

Interaction

  • with diuretics
  • with insulin or insulin secretagogues
  • avoid monitoring glycemic control with urine glucose tests
  • drugs that reduce Metformin clearance
  • carbonic anhydrase inhibitors interaction
  • alcohol interaction

Contraindications

  • hypersensitivity to Empagliflozin and Metformin
  • acute metabolic acidosis
  • severe renal failure
  • acute conditions altering renal function
  • diseases causing tissue hypoxia
  • hepatic impairment
  • acute alcohol intoxication

Side Effects

  • urinary tract infection
  • genital mycotic infections
  • diarrhea
  • nausea/vomiting
  • flatulence
  • abdominal discomfort
  • hypoglycemia
  • vaginal moniliasis
  • volume depletion
  • urticaria
  • dysuria

Pregnancy & Lactation

  • risks during second and third trimesters
  • not recommended during breastfeeding

Precautions & Warnings

  • lactic acidosis
  • hypotension
  • ketoacidosis
  • acute kidney injury & impairment in renal function
  • urosepsis, pyelonephritis, Fournier’s gangrene & genital mycotic infections
  • hypoglycemia
  • Vitamin B12 Deficiency
  • increased LDL-C
  • macrovascular outcomes

Overdose Effects

  • no toxicity observed in controlled clinical studies
  • lactic acidosis in case of Metformin overdose
  • treatment should be initiated as appropriate

Therapeutic Class

Combination Oral hypoglycemic preparations

Storage Conditions

Keep below 30°C temperature, protected from light & moisture, Keep out of the reach of children

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