Lepsytam 500 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)

Strip Price: ৳ 300.00

Medicine Details

Category	Details
Generic	Levetiracetam
Company	Healthcare pharmaceuticals ltd
Also available as	Lepsytam 250 mg tablet Lepsytam 500 mg injection Lepsytam 500 mg oral solution

Monotherapy in treatment of partial-onset seizures in adults and adolescents
Adjunctive therapy in treatment of partial-onset seizures in adults, adolescents, children and infants
Treatment of myoclonic seizures in adults and adolescents with Juvenile Myoclonic Epilepsy
Treatment of primary generalized tonic-clonic seizures in adults and adolescents with Idiopathic Generalised Epilepsy

Precise mechanism is unknown
Minimal activity in submaximal stimulation and threshold tests
Protection observed against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid
Inhibits burst firing without affecting normal neuronal excitability

Recommended starting dose for adults and adolescents from 16 years of age is 250 mg twice daily
Initial therapeutic dose for adults (≥18 years) and adolescents (12 to 17 years) weighing 50 kg or more is 500 mg twice daily
Tablet formulation not adapted for use in infants and children under the age of 6 years
Monotherapy safety and efficacy not established for children and adolescents below 16 years
Pediatric add-on therapy starting dose for child or adolescent of 25 kg is 250 mg twice daily

Flm-coated tablets must be taken orally, swallowed with sufficient quantity of liquid
Administered in two equally divided doses

No influence on serum concentrations of existing antiepileptic medicinal products
Probenecid inhibits renal clearance of the primary metabolite but not of Lepsytam
Concomitant administration with methotrexate may decrease methotrexate clearance
Reports of decreased Lepsytam efficacy when osmotic laxative macrogol is concomitantly administered
No alteration in absorption by food, but rate of absorption slightly reduced

Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Most common adverse reactions include somnolence, asthenia, infection, dizziness in adult patients
In pediatric patients: fatigue, aggression, nasal congestion, decreased appetite, irritability

Not recommended during pregnancy and in women of childbearing potential not using contraception unless clinically necessary
Excreted in human breast milk, breastfeeding not recommended

Dose adjustment may be required for patients with renal impairment
Rare cases of decreased blood cell counts have been described at beginning of treatment
Monitoring for signs of depression and/or suicidal ideation and behaviours recommended
Tablet formulation not adapted for use in infants and children under the age of 6 years

Adjustment of dose recommended in elderly patients with compromised renal function
Renal function-dependent individualized daily dose
No dose adjustment needed in patients with mild to moderate hepatic impairment

Somnolence, agitation, aggression, depressed level of consciousness, respiratory depression and coma observed
No specific antidote available
Symptomatic treatment may include haemodialysis

Store at a cool temperature (not exceeding 25°C) and dry place, protected from light