Olakin 150 mg (Tablet)
Unit Price: ৳ 700.00 (1 x 30: ৳ 21,000.00)
Strip Price: ৳ 21,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | Ziska pharmaceuticals ltd |
Indications
- Breast Cancer
- Ovarian Cancer
- HR-positive breast cancer
- Platinum sensitive relapsed cancer
- Neoadjuvant treatment
- Adjuvant treatment
- Metastatic setting
- Maintenance treatment
Pharmacology
- Inhibitor of PARP enzymes
- Inhibition of tumor cell growth
- DNA repair
- Cell cycle regulation
- Cytotoxicity
- Anti-tumor activity
- Increased formation of PARP-DNA complex
- Disruption of cellular homeostasis
Dosage
- Recommended dose of 400 mg
- Oral administration
- Twice daily dosing
- Dose reduction for adverse reactions
- Dose modifications for CYP3A inhibitors
- Dose modifications for renal impairment
- Pediatric use not established
Interaction
- Potentiation of myelosuppressive toxicity
- CYP3A inhibitors
- CYP3A inducers
- Contraindicated drugs
- Avoidance of grapefruit and grapefruit juice
Contraindications
- Hypersensitivity to the drug or its ingredients
Side effects
- Common serious adverse reaction: anemia
- Dermatitis allergic reported
- Neutrophil count decreased
- Platelet count decreased
- Discontinuation due to adverse events
Pregnancy lactation
- Potential fetal harm
- Embryo-fetal toxicity
- Not recommended during pregnancy
- Consideration for nursing mothers
Precautions warnings
- Incidence of Myelodysplastic Syndrome/Acute Myeloid Leukemia
- Fatal outcome in MDS/AML cases
- Pneumonitis occurrence
- Regular hematological monitoring
- Prompt assessment of respiratory symptoms
Overdose effects
- No established symptoms of overdose
- General supportive measures
Therapeutic class
- Targeted Cancer Therapy
Storage conditions
- Store below 30°C
- Protect from light
- Keep out of the reach of children