G-Meropenem 500 mg/vial (IV Injection or Infusion)
500 mg vial: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Meropenem trihydrate |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Indications
- Pneumonia and Nosocomial Pneumonia
- Urinary Tract Infections
- Intra-abdominal Infections
- Gynaecological Infections
- Skin and Skin Structure Infections
- Meningitis
- Septicaemia
- Pulmonary infections in cystic fibrosis
- Empiric treatment for presumed infections in patients with febrile neutropenia
Pharmacology
Bactericidal action by interfering with bacterial cell wall synthesis
Dosage
- Recommended daily dosage varies for adults and children
- Various dosage guidelines based on infection type and severity
Administration
Administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over 3-5 minutes
Interaction
- Probenecid interaction leading to increased elimination half-life and plasma concentration
- Reduction in serum valproic acid levels
Contraindications
Hypersensitivity to the product
Side Effects
- Inflammation
- Thrombophlebitis
- Pain at injection site
- Skin reactions like rash, pruritus, urticaria
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Headache
Pregnancy & Lactation
Pregnancy Category B, caution during breastfeeding
Precautions & Warnings
- Discontinue drug in case of allergic reaction
- Careful monitoring of transaminase and bilirubin levels in hepatic disease patients
Use in Special Populations
- Dosage adjustments based on renal impairment
- No dosage adjustments required in hepatic impairment
- No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
Overdose Effects
Accidental overdose could occur, treatment should be symptomatic
Therapeutic Class
Other beta-lactam Antibiotics
Reconstitution
Preparation of solution for intravenous bolus or infusion administration
Compatibility with Infusion Fluids
- 0.9% sodium chloride intravenous infusion
- 5% or 10% glucose intravenous infusion
- 5% glucose intravenous infusion with 0.02% sodium bicarbonate
- 5% glucose and 0.9% sodium chloride intravenous infusion
- 5% glucose with 0.225% sodium chloride intravenous infusion
- 5% glucose with 0.15% potassium chloride intravenous infusion
- 2.5% and 10% mannitol intravenous infusion
- normosol-M in 5% glucose intravenous infusion
Potency Maintenance
Freshly reconstituted solution recommended, potency maintained for up to 3 hours at up to 25°C or 13 hours at up to 5°C
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture, keep out of the reach of children