G-Metoprolol 50 mg (Tablet)
Unit Price: ৳ 1.15 (10 x 10: ৳ 115.00)
Strip Price: ৳ 11.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Gonoshasthaya pharma ltd |
Indications
- Management of hypertension
- Management of angina pectoris
- Treatment of cardiac arrhythmias
- Adjunct treatment of hyperthyroidism
- Reduction in infarct size in acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Inhibits the agonistic effect of catecholamines on the heart
- Reduces heart rate, cardiac output, contractility, and blood pressure
- Interferes less with insulin release and carbohydrate metabolism
- Interferes much less with cardiovascular response to hypoglycemia
Dosage & Administration
- Total daily dosage ranges from 100-400 mg for hypertension
- Initial dose of 100 mg per day for hypertension
- Increased dosage for uncontrolled hypertension
- 50-100 mg for angina pectoris
- Up to 300 mg per day for cardiac arrhythmias
- 50 mg four times a day for hyperthyroidism
- Oral therapy for myocardial infarction
- Extended-release tablet dosage varies for different conditions
- IV Injection dosage for arrhythmias and myocardial infarction
Interaction
- Additive effect with catecholamine‐depleting drugs
- Increased concentration with drugs inhibiting CYP2D6
- Risk of bradycardia when used with digitalis glycosides
- Potential exacerbation of rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Hypersensitivity to Metoprolol or other B-blockers
- Complicated myocardial infarction with specific conditions
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Mental confusion
- Headache
- Somnolence
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution in nursing women
Precautions & Warnings
- Use with caution in patients with bronchospastic disease
- Controversial withdrawal prior to major surgery
- Masking of tachycardia with hypoglycemia
- Aggravation of arterial insufficiency
- Caution in patients treated with Calcium Channel Blockers
Use in Special Populations
- Use with caution in patients with impaired hepatic function
- No clinically relevant differences in pediatric patients
- No notable differences in older and younger patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
Storage Conditions
- Store in a cool and dry place
- Protected from light