Vorizol 200 mg/vial (IV Injection)
200 mg vial: ৳ 2,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Drug international ltd |
| Also available as |
Indications
- Invasive aspergillosis
- Candidemia
- Disseminated candidiasis
- Esophageal candidiasis
- Scedosporium apiospermum infections
- Fusarium species infections
- Refraction to other therapy
Pharmacology
- Triazole antifungal medication
- Inhibition of ergosterol synthesis
- Binding and inhibition of CYP450-dependent 14-alpha sterol demethylase
Dosage & Administration
- Oral administration
- Loading dose regimen
- Maintenance dose regimen
- Injection for invasive aspergillosis
- Injection for candidemia and deep tissue Candida infections
- Injection for Scedosporiosis and Fusariosis
Interaction
- CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Increase maintenance oral and intravenous dosage with co-administration of certain drugs
Contraindications
- Hypersensitivity to Voriconazole or any other components
- Co-administration with specific drugs leading to serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to fetus
Precautions & Warnings
- Careful assessment of benefit-risk balance for long term exposure
- Reported association with squamous cell carcinoma of the skin (SCC) with long-term treatment
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No available data on overdose effects
Therapeutic Class
- Other antifungal preparations
Reconstitution
- Shake the bottle well before adding water
- Add 25 ml of boiled and cooled water to the bottle
- Shake vigorously until the powder is completely mixed with water
- Store reconstituted suspension between 15°C-30°C
- Discard suspension 14 days after reconstitution
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C and protected from light
- Store Vorizol powder for suspension between 2°C-8°C