Dotin 1 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dotinurad |
| Company | General pharmaceuticals ltd |
| Also available as | Dotin 05 mg tabletDotin 2 mg tablet |
Indications
- Treatment of gout
- Treatment of hyperuricemia
Pharmacology
- Selective inhibition of URAT1
- Increase in urinary urate excretion
- Lowering serum urate levels
- Weak inhibitory effects on ABCG2, OAT1, and OAT3
Dosage & Administration
- Usual adult dosage: 0.5 mg once daily
- Maintenance dose: 2 mg once daily
- Maximum dose: 4 mg once daily
- Precautions for gouty arthritis induction
- Instructions for missing dose and overdose
Interaction
- Interaction with Pyrazinamide
- Interaction with Salicylic acid preparations (Aspirin)
Contraindications
- Contraindicated in patients with known hypersensitivity to the drug component
Side Effects
- Most commonly reported side effects: gouty arthritis, limb discomfort
- Less common side effects: loose stools, increased y-GTP, arthralgia, kidney stones, nephrocalcinosis, increased urinary y2 macroglobulin, increased blood creatinine, increased urine albumin/creatinine ratio, positive urine albumin
Pregnancy & Lactation
- Use during pregnancy if therapeutic benefits outweigh risks
- Excretion in breast milk
- Consult doctor before breastfeeding
Precautions & Warnings
- Precautions for gouty arthritis
- Caution for patients with urolithiasis
- Consideration for patients with renal impairment
- Careful follow-up for patients with hepatic impairment
Therapeutic Class
- Drugs used in Gout
- Urate reabsorption inhibitor
Storage Conditions
- Store below 30°C and dry place
- Keep away from light
- Keep out of the reach of children