Surliv 300 mg (Tablet)
Unit Price: ৳ 26.00 (2 x 10: ৳ 520.00)
Strip Price: ৳ 260.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
- Reduces cholesterol saturation of bile
- Promotes dissolution of gallstones
- Reduces cholesterol secretion into bile
- Increases bile acid secretion rate
Pharmacology
- Decreases secretion of cholesterol in bile
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Promotes formation of liquid cholesterol crystal complexes
- Protects cholangiocytes against cytotoxicity of hydrophobic bile acids
- Stimulates hepatobilliary secretion
- Protects hepatocytes against bile acid-induced apoptosis
- Completely absorbed in the upper intestine
- Rate of absorption ranges from 60-80%
- Enters the portal vein and undergoes extraction from portal blood by liver
- Conjugated with amino acid (glycine or taurine)
- Secreted into the hepatic bile ducts
- Biologic half-life ranges from 3.5-5.8 days
Dosage & Administration
- Dissolution of Gallstones: 8-12 mg/kg/day
- Primary Billiary Cirrhosis: 10-15 mg/kg/day
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
Interaction
- Avoid concomitant administration with bile-acid binding drugs
- Avoid use with drugs that increase bile cholesterol
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
- Pregnancy category B
- No reported harm during pregnancy
- Effectively used for cholestasis of pregnancy during last trimester
- No documented problems regarding breastfeeding
Precautions & Warnings
- Use cautiously in those with liver disease
Therapeutic Class
- Anti-gallstones drugs
- Bile Acids
Storage Conditions
- Store below 25°C
- Protected from light and moisture
- Keep out of reach of children