Aknill 20 mg (Capsule)
Unit Price: ৳ 75.00 (1 x 10: ৳ 750.00)
Strip Price: ৳ 750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Isotretinoin oral |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment for severe forms of acne
- Indicated for nodular or conglobate acne
- Resistant to standard therapy with systemic antibacterials and topical therapy
Pharmacology
- Alters cell cycle and differentiation
- Reduces sebum production
- Prevents blockage of pores
- Reduces growth of acne causing bacteria
- Little to no affinity for retinol binding proteins
- Induces apoptosis in sebocytes
- Reduces the formation of comedones
- Does not directly kill bacteria
Dosage & Administration
- Taken once or twice daily with food
- Initial dose of 0.5 mg/kg daily
- Dosage adjustment during therapy
- Long-term remission related to total dose administered
- Treatment duration of 16-24 weeks
- Lower starting dose for severe renal insufficiency
- Not indicated for prepubertal acne
- Continued lower dose for intolerance
Interaction
- Additive adverse effects with vit A or its derivatives
- Decreased efficacy of microdosed progesterone
- Increased risk of local irritation with topical keratolytic or exfoliative anti-acne agents
- Reduced efficacy with oxidising agents
Contraindications
- Contraindicated in pregnant or breastfeeding women
- Contraindicated in patients with hypersensitivity to Isotretinoin or excipients
- Contraindicated in patients with hepatic insufficiency
- Contraindicated in patients with excessively elevated blood lipid values
- Contraindicated in patients receiving concurrent treatment with tetracyclines
Side Effects
- Dryness of the skin and mucosae (e.g., lips, nasal, eyes)
- Infections
- Blood and lymphatic system disorders
- Immune system disorders
- Metabolism and nutrition disorders
- Psychiatric disorders
- Nervous system disorders
- Eye disorders
- Ear and labyrinth disorders
- Vascular disorders
- Respiratory, thoracic, and mediastinal disorders
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin and subcutaneous tissues disorders
- Musculo-skeletal and connective tissue disorders
- Renal and urinary disorders
- General disorders and administration site conditions
- Overdose
Pregnancy & Lactation
- Absolute contraindication for pregnant or breastfeeding women
- Risks of severe malformation of the fetus
- Increased incidence of spontaneous abortion
- Passage of Isotretinoin into human milk
Precautions & Warnings
- Comprehensive information on pregnancy prevention for female patients
- Medically supervised pregnancy tests
- Limited prescription for women of childbearing potential
- Precautions for male patients
- Avoidance of intense sunlight or UV rays
- Precautions for psychiatric disorders
- Avoidance of concurrent administration with topical keratolytic agents
- Avoidance of aggressive chemical dermabrasion and cutaneous laser treatment
- Instructions for skin moisturising and lip balm use
- Precautions for eye disorders
- Bone changes and musculo-skeletal precautions
- Benign intracranial hypertension precautions
- Hepatobiliary precautions
- Renal insufficiency precautions
- Lipid metabolism precautions
- Gastrointestinal disorders precautions
- Precautions for high-risk patients
Therapeutic Class
- Oral retinoids for Acne
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children