Aknill 10 mg (Capsule)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Isotretinoin oral |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Severe forms of acne
- Nodular acne
- Conglobate acne
- Acne at risk of permanent scarring
- Resistant to standard therapy
- Systemic antibacterials
- Topical therapy
Pharmacology
- Alters cell cycle
- Alters cell differentiation
- Reduces sebum production
- Prevents pore blockage
- Reduces acne causing bacteria growth
- Induces apoptosis in sebocytes
- Reduces hyperkeratinization
- Reduces formation of comedones
- Induces apoptosis in sebocytes
- Reduces sebum duct size
- Makes microenvironment less hospitable to bacteria
Dosage & Administration
- Taken with food
- Prescribed by or under supervision of experienced physicians
- Started at a dose of 0.5 mg/kg daily
- Dose adjustment during therapy
- Treatment course of 16-24 weeks
- Complete clearing of acne with single treatment course
- Lower dose for severe renal insufficiency
- Higher risk of relapse with lower dose in intolerant patients
Interaction
- Additive adverse effects with vit A or its derivatives
- Decreased efficacy with microdosed progesterone
- Increased risk of local irritation with topical keratolytic or exfoliative anti-acne agents
- Reduced efficacy with oxidising agents like benzoyl peroxide
Contraindications
- Contraindicated in pregnant or breastfeeding women
- Contraindicated in women of childbearing potential without meeting pregnancy prevention conditions
- Contraindicated in patients with hypersensitivity to Isotretinoin or excipients
- Contraindicated in patients with hepatic insufficiency
- Contraindicated in patients with excessively elevated blood lipid values
- Contraindicated in patients receiving concomitant treatment with tetracyclines
Side Effects
- Dryness of the skin
- Dryness of the mucosae (e.g. lips, nasal mucosa, eyes)
- Infections
- Anaemia
- Neutropenia
- Headache
- Blepharitis
- Epistaxis
- Pruritus
- Arthralgia
- Myalgia
- Transaminase increased
- Pruritus
- Rash erythematous
- Dermatitis
- Cheilitis
- Depression
- Anxiety
- Psychotic symptoms
- Visual disturbances
- Hearing impairment
- Vasculitis
- Gastrointestinal disorders
- Hepatobiliary disorders
- Glomerulonephritis
- Malaise
- Overdose symptoms
- Pharmaceutical precautions
Pregnancy & Lactation
- Absolute contraindication in pregnancy
- Increased risk of severe foetal malformations
- Increased incidence of spontaneous abortion
- Highly lipophilic - passage into human milk likely
- Contraindicated in nursing mothers
Precautions & Warnings
- Comprehensive contraception information for female patients
- Medically supervised pregnancy tests
- Follow-up visits at 28 day intervals
- Prescribing and dispensing restrictions for women of childbearing potential
- Male patients must not share medication with females
- Patients should not donate blood during therapy and for 1 month after discontinuation
- Psychiatric disorders monitoring
- Skin and subcutaneous tissues precautions
- Eye disorders precautions
- Musculo-skeletal and connective tissue precautions
- Benign intracranial hypertension precautions
- Hepatobiliary disorders precautions
- Renal insufficiency precautions
- Lipid Metabolism precautions
- Gastrointestinal disorders precautions
- High Risk Patients precautions
Therapeutic Class
- Oral retinoids for Acne
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children