Tripar 5 mg (Tablet)
Unit Price: ৳ 12.00 (4 x 14: ৳ 672.00)
Strip Price: ৳ 168.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in cerebral cortex
Dosage & Administration
- Initial low dose, gradually increased
- Individualized dosage
- Preferably given before or after meals based on patient reaction
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- May intensify anticholinergic effects of monoamine oxidase inhibitors and tricyclic antidepressants
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary retention
- Tachycardia
- Dilation of the pupils
Pregnancy & Lactation
- Use during pregnancy only if benefit outweighs risk
- Caution when administered to nursing women
- May cause suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Close monitoring of intraocular pressures
- Caution in hot weather and with other atropine-like drugs
- Possible occurrence of anhidrosis and hyperthermia
Overdose Effects
- Typical central symptoms of atropine intoxication
- Recognition of peripheral signs of parasympathetic blockade
- Neuropsychiatric signs such as delirium, disorientation, seizures
- Treatment involves symptomatic and supportive therapy
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light