Esprazo 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Pacific pharmaceuticals ltd
Also available as
Esprazo 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Plasma protein binding is constant over the concentration range
  • Metabolized in the liver
  • Plasma elimination half-life of esomeprazole is approximately 1–1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for Healing of Erosive Esophagitis
  • 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • 40 mg Once Daily for Helicobacter Pylori eradication in combination therapy
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • Dosage form also includes IV Injection or IV infusion for different conditions and patient categories

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken with water and administered carefully through nasogastric or gastric tube
  • IV Injection must be administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Potential interference with CYP2C19, diazepam, and drugs requiring particular gastric pH for bioavailability
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin

Contraindications

  • Known hypersensitivity to the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Breastfeeding should be discontinued if the use of esomeprazole is considered essential

Precautions & Warnings

  • Symptomatic response to therapy with Esprazo does not preclude the presence of gastric malignancy
  • Special instructions for patients who have difficulty swallowing capsules
  • Use of antacids may be allowed while taking Esprazo

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal to rats at high doses
  • Major signs of acute toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure provided in image form

Common Questions about Esprazo 20 mg Tablet

  • Proton pump inhibitor used to treat various conditions related to stomach acid
  • Multiple uses including relief from heartburn, healing erosive esophagitis, and preventing its recurrence
  • Common side effects and precautions
  • Usage during pregnancy or breastfeeding
  • Time it takes to start working

Mode of Action

  • Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor providing better acid control than racemic proton pump inhibitors
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Plasma protein binding is constant over the concentration range of 2 20 mmol/L

Distribution

  • Esomeprazole is 97% bound to plasma proteins
  • Apparent volume of distribution at steady state in healthy volunteers is approximately 16 L

Metabolism

  • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • The major part of esomeprazole’s metabolism is dependent upon the CYP2C19 isoenzyme

Excretion

  • Plasma elimination half-life of esomeprazole is approximately 1–1.5 hours
  • Less than 1% of parent drug is excreted in the urine

Combination Therapy with Antimicrobials

  • Esomeprazole magnesium 40 mg once daily given in combination with clarithromycin 500 mg twice daily and amoxicillin 1000 mg twice daily for 7 days

Cautions

  • Immediate medical attention advised for specific symptoms
  • Long-term use may cause weak bones and mineral deficiencies
  • Special use instructions for patients with swallowing difficulties

Chemical Formula

  • C17H19N3O3S

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