Regenox 5% (Scalp Solution)

Indications

• Treatment of androgenic alopecia in males and females
• Stabilisation of hair loss in patients with androgenic alopecia
• Treatment of alopecia areata

Pharmacology

• Stimulates hair growth
• Increases oxygen, blood, and nutrients supply to the hair follicle
• Widens blood vessels
• Inhibits androgen hormone affecting hair follicles
• Absorption rate through the skin
• Excretion in the urine

Dosage & Administration

• Applied to clean and dry hair and scalp
• Twice-daily application at 12-hour intervals
• Total daily application dose should not exceed 2 ml
• Should remain on the scalp for about 4 hours before washing
• Should not be massaged into the scalp
• Should not be mixed with any hair oil
• Should not be used more than two times a day
• Should not be taken orally or applied to any other part of the body
• Hands should be washed immediately if applied with the fingertips
• May require 4 months or more for evidence of hair growth
• Should be used for not less than 45 days to arrest hair fall
• Particular strength may be selected based on the severity of hair loss or type and extent of baldness

Interaction

• Should not be used with other topical agents known to alter the stratum corneum barrier such as tretinoin or dithranol
• Theoretical possibility of absorbed Regenox potentiating orthostatic hypotension caused by peripheral vasodilators

Contraindications

• Patients with cardiac abnormalities
• Children below 18 years of age
• Patients using occlusive dressings or other medicines on the scalp
• Patients with red, inflamed infection, or irritated or painful scalp (including psoriasis & sunburn)

Side Effects

• Minor dermatological reactions
• Dermatitis or hypertrichosis may occur
• 0.1-5% incidence

Pregnancy & Lactation

• Should not be used during pregnancy and lactation

Precautions & Warnings

• More likely to cause scalp irritation
• Use should be stopped if scalp irritation continues or worsens

Overdose Effects

• Increased systemic absorption may occur if higher-than-recommended doses are applied to larger surface areas of the body or areas other than the scalp
• No known cases of overdosage resulting from topical administration
• Signs and symptoms would primarily be cardiovascular effects associated with sodium and water retention, and tachycardia
• Fluid retention can be managed with appropriate diuretic therapy
• Clinically significant tachycardia can be controlled by administration of a beta-adrenergic blocking agent

Therapeutic Class

• Other scalp preparations

Storage Conditions

• Store at a cool and dry place
• Protected from light
• Keep out of the reach of children

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