Renesis 70 mg (Tablet)
Unit Price: ৳ 500.00 (2 x 3: ৳ 3,000.00)
Strip Price: ৳ 1,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Treatment for symptomatic anemia associated with chronic kidney disease (CKD)
Description
- First-in-class HIF-PH inhibitor
- Orally administered
- Promotes erythropoiesis
- Increases endogenous production of erythropoietin
- Improves iron regulation
- Overcomes EPO-suppressive effects of inflammation
- Downregulates hepcidin
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Increases endogenous erythropoietin production
- Reduces expression of the peptide hormone hepcidin
- Improves iron availability
- Boosts hemoglobin (Hb) levels
- Regulates the expression of genes responding to reduced oxygen levels
Dosage & Administration
- Oral administration
- Taken three times per week
- Individualized dose to achieve and maintain target Hb levels
- Dosing adjustment guidelines
- Method of administration with or without food
Interaction
- Possible drug-drug interactions with phosphate binders, gemfibrozil, probenecid, OATP1B1, BCRP substrates
Side Effects
- Common adverse reactions such as hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, nausea
Pregnancy & Lactation
- Contraindicated during pregnancy and breastfeeding
Precautions & Warnings
- May initiate thrombotic vascular events (TVEs)
- Use with caution in patients with pre-existing risk factors for TVE
- Use with caution in patients with a history of seizures
- Avoid use in serious signs and symptoms of infection
- Avoid use in patients with liver disorder
- Avoid initiation in pregnant women
Use in Special Populations
- Not indicated for use in children
- Not recommended for patients with severe hepatic impairment
Overdose Effects
- Increased heart rate reported in healthy adult
- Likely increase in hemoglobin concentration
- Appropriate measures of dose reduction or interruption needed
- Not removed by dialysis
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool, dry place below 30°C, away from light and moisture