Dam 0.5 mg+10 mg (Tablet)

Title and Categories

• Flupentixol and Melitracen Tablet
• Combines anxiolytics & anti-depressant drugs

Indications

• Anxiety
• Depression
• Apathy
• Psychogenic depression
• Depressive neurosses
• Masked depression
• Psychosomatic affections accompanied by anxiety and apathy
• Menopausal depressions
• Dysphoria and depression in alcoholics and drug addicts

Pharmacology

• Contains flupentixol and melitracen
• Flupentixol has anxiolytic and antidepressant properties
• Melitracen has activating properties in low doses
• Combination provides antidepressant, anxiolytic, and activating properties
• Maximal serum concentration reached in about 4 hours for both compounds
• Biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours

Dosage & Administration

• Adults: Usually 2 tablets orally daily in the morning and noon
• In severe cases, the morning dose may be increased to 2 tablets
• Elderly patients: 1 tablet in the morning
• Maintenance dose: Usually 1 tablet orally in the morning
• Additional treatment with a sedative in the acute phase is recommended for cases of insomnia or severe restlessness

Interaction

• Enhances the response to alcohol, barbiturates, and other CNS depressants
• Simultaneous administration with MAO-inhibitors may cause hypertensive crises
• Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds
• Thymoleptics enhance the effects of adrenaline and noradrenaline

Contraindications

• Immediate recovery phase after myocardial infarction
• Defects in bundle-branch conduction
• Untreated narrow-angle glaucoma
• Acute alcohol, barbiturate and opiate intoxications
• Not to be given to patients who have received an MAO-inhibitor within two weeks
• Not recommended for excitable or overactive patients due to its activating effect

Side Effects

• Rare in recommended doses
• Transient restlessness and insomnia

Pregnancy & Lactation

• Not recommended during pregnancy and lactation

Precautions & Warnings

• If previously treated with tranquillizers with sedative effect, withdrawal should be gradual

Overdose Effects

• Symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate
• Symptomatic and supportive measures required
• Gastric lavage should be carried out as soon as possible
• Activated charcoal may be administered
• Measures aimed at supporting the respiratory and cardiovascular systems should be instituted
• Epinephrine (adrenaline) must not be used
• Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden

Storage Conditions

• Store at a temperature not exceeding 30°C in a dry place
• Protect from light
• Keep out of reach of children

FAQs

• Consists of Flupentixol & Melitracen
• Helps treat anxiety and depression
• Can cause dizziness and sleepiness
• Caution while driving or doing tasks requiring concentration
• Avoid alcohol consumption
• May cause changes in blood sugar levels
• Inform doctor about certain health conditions
• Notify doctor about mood changes or suicidal thoughts
• Inform doctor before surgical procedures

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