Empaglif-M 5 mg+1000 mg (Tablet)
Unit Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- In patients insufficiently controlled on Metformin alone
- In combination with other medicinal products for diabetes
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Take twice daily with meals
- Dose escalation should be gradual
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
- Extended-release formulations available
- Renal impaired patient assessment required
- Not recommended for pediatric patients under 18 years of age
Interaction
- Co-administration with diuretics
- Co-administration with insulin or insulin secretagogues
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that reduce Metformin clearance
- Carbonic Anhydrase Inhibitors
- Drugs affecting glycemic control
- Avoid excessive alcohol intake
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure (GFR <30 ml/min)
- Conditions altering renal function
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Serum lipids increased
- Volume depletion
- Urticaria
- Dysuria
- Blood creatinine increased
- Glomerular filtration rate decreased
- Haematocrit increased
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity observed at high doses
- Hypoglycemia not seen at high Metformin doses
- Lactic acidosis is a medical emergency
- Haemodialysis for removal of lactate and Metformin
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children