Empaglif-M 5 mg+1000 mg (Tablet)

Unit Price: ৳ 20.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Aristopharma ltd
Also available as
Empaglif m 5 mg tablet Empaglif m 125 mg tablet Empaglif m 125 mg tablet Empaglif m xr 10 mg tablet Empaglif m xr 25 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • In patients insufficiently controlled on Metformin alone
  • In combination with other medicinal products for diabetes

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Take twice daily with meals
  • Dose escalation should be gradual
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
  • Extended-release formulations available
  • Renal impaired patient assessment required
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Co-administration with diuretics
  • Co-administration with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance
  • Carbonic Anhydrase Inhibitors
  • Drugs affecting glycemic control
  • Avoid excessive alcohol intake

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure (GFR <30 ml/min)
  • Conditions altering renal function
  • Hepatic impairment
  • Acute alcohol intoxication

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection
  • Thirst
  • Taste disturbance
  • Pruritus
  • Rash
  • Increased urination
  • Serum lipids increased
  • Volume depletion
  • Urticaria
  • Dysuria
  • Blood creatinine increased
  • Glomerular filtration rate decreased
  • Haematocrit increased
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity observed at high doses
  • Hypoglycemia not seen at high Metformin doses
  • Lactic acidosis is a medical emergency
  • Haemodialysis for removal of lactate and Metformin

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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