Empaglif-M 12.5 mg+500 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on Metformin
- Combination therapy with other diabetes medications
- Patients already being treated with Empagliflozin and Metformin separately
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Take twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
- Extended-release formulations available
- Adjust dosing for renal impaired patients
- Not recommended for pediatric patients under 18 years of age
Interaction
- Co-administration with diuretics
- Co-administration with insulin or insulin secretagogues
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that reduce Metformin clearance
- Carbonic anhydrase inhibitors
- Drugs affecting glycemic control
- Alcohol potentiation effect on Metformin
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Alcohol intoxication
Side Effects
- Urinary tract infection
- Genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Vulvovaginitis
- Balanitis
- Urticaria
- Dysuria
- Volume depletion
- Lactic acidosis
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment
- Risk for urinary tract infections
- Hypoglycemia risk
- Vitamin B12 deficiency
- Increased LDL-C
- Macrovascular risk reduction evidence not established
Overdose Effects
- Empagliflozin and Metformin overdose effects
- Toxicity studies with high doses
- No hypoglycemia with Metformin overdose
- Lactic acidosis medical emergency
- Treatment options for overdose
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children