Empaglif-M 12.5 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Aristopharma ltd
Also available as
Empaglif m 5 mg tablet Empaglif m 5 mg tablet Empaglif m 125 mg tablet Empaglif m xr 10 mg tablet Empaglif m xr 25 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on Metformin
  • Combination therapy with other diabetes medications
  • Patients already being treated with Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Take twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
  • Extended-release formulations available
  • Adjust dosing for renal impaired patients
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Co-administration with diuretics
  • Co-administration with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance
  • Carbonic anhydrase inhibitors
  • Drugs affecting glycemic control
  • Alcohol potentiation effect on Metformin

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Alcohol intoxication

Side Effects

  • Urinary tract infection
  • Genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Vulvovaginitis
  • Balanitis
  • Urticaria
  • Dysuria
  • Volume depletion
  • Lactic acidosis

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment
  • Risk for urinary tract infections
  • Hypoglycemia risk
  • Vitamin B12 deficiency
  • Increased LDL-C
  • Macrovascular risk reduction evidence not established

Overdose Effects

  • Empagliflozin and Metformin overdose effects
  • Toxicity studies with high doses
  • No hypoglycemia with Metformin overdose
  • Lactic acidosis medical emergency
  • Treatment options for overdose

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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