Empaglif-M 12.5 mg+1000 mg (Tablet)

Unit Price: ৳ 28.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Aristopharma ltd
Also available as
Empaglif m 5 mg tablet Empaglif m 5 mg tablet Empaglif m 125 mg tablet Empaglif m xr 10 mg tablet Empaglif m xr 25 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • In patients insufficiently controlled on Metformin
  • In combination with other medicinal products for diabetes
  • In patients treated with Empagliflozin and Metformin separately

Pharmacology

  • Empagliflozin inhibits Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Decreases hepatic glucose production
  • Increases insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Take combination twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily doses for Metformin Hydrochloride and Empagliflozin
  • Extended-release formulations available
  • Assess renal function before initiating
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Increased urine volume and frequency of voids with diuretics
  • Increased risk for hypoglycemia with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance may increase accumulation
  • Carbonic anhydrase inhibitors may increase risk of lactic acidosis
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication
  • Alcoholism

Side Effects

  • Urinary tract infection and female genital mycotic infections
  • Diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache
  • Hypoglycemia, gastrointestinal symptoms, vaginal moniliasis, vulvovaginitis, balanitis, urinary tract infection
  • Volume depletion, urticaria, dysuria, blood creatinine increased, haematocrit increased
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Postmarketing cases of Metformin Hydrochloride-associated lactic acidosis
  • Assessment and correction of volume status before initiating
  • Assessment for ketoacidosis in patients presenting with signs and symptoms of metabolic acidosis
  • Consideration of temporarily discontinuing in settings of reduced oral intake or fluid losses
  • Increased risk for urinary tract infections
  • Consideration of lowering insulin dose to reduce risk of hypoglycemia
  • Monitoring of vitamin B12 levels
  • Monitoring and treatment of increased LDL-C

Overdose Effects

  • No toxicity seen with single doses up to 800 mg Empagliflozin
  • No hypoglycemia seen with Metformin doses up to 85 g
  • Lactic acidosis is a medical emergency and must be treated in hospital
  • Treatment initiation appropriate to patient's clinical status
  • Most effective method to remove lactate and Metformin is haemodialysis

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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