Empaglif-M XR 25 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 45.00 (2 x 6: ৳ 540.00)
Strip Price: ৳ 270.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Aristopharma ltd
Also available as
Empaglif m 5 mg tablet Empaglif m 5 mg tablet Empaglif m 125 mg tablet Empaglif m 125 mg tablet Empaglif m xr 10 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus as an adjunct to diet and exercise
  • Treatment in patients insufficiently controlled on their maximally tolerated dose of Metformin alone
  • Combination with other medicinal products for the treatment of diabetes
  • Treatment in patients already being treated with the combination of Empagliflozin and Metformin as separate tablets

Pharmacology

  • Empagliflozin inhibits Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug

Dosage & Administration

  • Dosage individualized based on effectiveness and tolerability
  • Take the combination twice daily with meals
  • Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
  • Extended-release formulations available
  • Renal impaired patient assessment required
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Co-administration with diuretics increases urine volume and frequency of voids
  • Increased risk for hypoglycemia with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance may increase the accumulation of Metformin
  • Carbonic Anhydrase Inhibitors may increase risk of lactic acidosis
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Any type of acute metabolic acidosis
  • Severe renal failure (GFR < 30 ml/min)
  • Acute conditions altering renal function
  • Disease causing tissue hypoxia
  • Hepatic impairment, acute alcohol intoxication, alcoholism

Side Effects

  • Most common adverse reactions associated with Empagliflozin: urinary tract infection and female genital mycotic infections
  • Most common adverse reactions associated with Metformin: diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache
  • Important adverse reactions: hypoglycemia, gastrointestinal symptoms, urinary tract infection, thirst, taste disturbance, pruritus, rash, increased urination, increased serum lipids

Pregnancy & Lactation

  • Potential risk to a fetus especially during the second and third trimesters
  • Not recommended when breastfeeding

Precautions & Warnings

  • Lactic Acidosis may occur
  • Assess and correct volume status before initiating
  • Assess patients presenting with signs and symptoms of metabolic acidosis for ketoacidosis
  • Temporary discontinuation in settings of reduced oral intake or fluid losses
  • Increased risk for urinary tract infections
  • Consider lowering the dose of insulin secretagogue or insulin to reduce the risk of hypoglycemia
  • Metformin Hydrochloride may lower vitamin B12 levels
  • Monitor and treat increased LDL-C as appropriate

Overdose Effects

  • Single doses of up to 800 mg Empagliflozin and multiple daily doses of up to 100 mg Empagliflozin did not show toxicity
  • Hypoglycemia has not been seen with Metformin doses of up to 85 g, although lactic acidosis has occurred
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated as appropriate to the patient's clinical status

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature, protected from light & moisture
  • Keep out of the reach of children

Related Brands