Empanor M 5 mg+500 mg (Tablet)
Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Concord pharmaceuticals ltd |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Inadequately controlled on maximally tolerated dose of Metformin alone
- In combination with other medicinal products for diabetes
- Already being treated with the combination of Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Take twice daily with meals
- Dose escalation should be gradual
- Maximum recommended daily doses for Metformin Hydrochloride and Empagliflozin
- Extended-release formulations available
- Adjust dosing based on effectiveness and tolerability
- Assess renal function before initiating
Interaction
- Co-administration with diuretics
- Co-administration with insulin or insulin secretagogues
- Avoid monitoring glycemic control with urine glucose tests
- Drugs that reduce Metformin clearance
- Carbonic anhydrase inhibitors
- Drugs affecting glycemic control
- Effects of alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Acute conditions altering renal function
- Disease causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine/Glomerular filtration rate
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity observed at high single or multiple doses
- Hypoglycemia not seen at high Metformin doses
- Lactic acidosis is a medical emergency
- Treatment should be initiated as appropriate
Therapeutic Class
Combination Oral hypoglycemic preparations
Storage Conditions
Keep below 30°C, protected from light & moisture, Keep out of the reach of children