Empanor M 5 mg+500 mg (Tablet)

Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00

Medicine Details

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Inadequately controlled on maximally tolerated dose of Metformin alone
  • In combination with other medicinal products for diabetes
  • Already being treated with the combination of Empagliflozin and Metformin as separate tablets

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Take twice daily with meals
  • Dose escalation should be gradual
  • Maximum recommended daily doses for Metformin Hydrochloride and Empagliflozin
  • Extended-release formulations available
  • Adjust dosing based on effectiveness and tolerability
  • Assess renal function before initiating

Interaction

  • Co-administration with diuretics
  • Co-administration with insulin or insulin secretagogues
  • Avoid monitoring glycemic control with urine glucose tests
  • Drugs that reduce Metformin clearance
  • Carbonic anhydrase inhibitors
  • Drugs affecting glycemic control
  • Effects of alcohol

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Acute conditions altering renal function
  • Disease causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication
  • Alcoholism

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection
  • Thirst
  • Taste disturbance
  • Pruritus
  • Rash
  • Increased urination
  • Increased serum lipids
  • Volume depletion
  • Urticaria
  • Dysuria
  • Increased blood creatinine/Glomerular filtration rate
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus during second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity observed at high single or multiple doses
  • Hypoglycemia not seen at high Metformin doses
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated as appropriate

Therapeutic Class

Combination Oral hypoglycemic preparations

Storage Conditions

Keep below 30°C, protected from light & moisture, Keep out of the reach of children

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