Dotiric 1 mg – Price, Uses, and Benefits for Bangladeshi Patients

Category	Details
Generic	Dotinurad
Company	Everest pharmaceuticals ltd
Also available as	Dotiric 05 mg tablet

Title

Dotinurad is indicated for the treatment of gout and hyperuricemia.
Dotinurad is a URAT1-selective urate reabsorption inhibitor that selectively inhibits URAT1 and inhibits urate reabsorption, thereby increasing urinary urate excretion and lowering serum urate levels. In addition, since it has weak inhibitory effects on ABCG2, OAT1 and OAT3 other than URAT143,44, it is expected to effectively lower serum uric acid levels without affecting uric acid secretion via these transporters. Thus, Dotinurad is a selective urate reabsorption inhibitor (SURI) that inhibits the reabsorption pathway mediated by URAT1 without inhibiting the uric acid secretion pathway mediated by ABCG2, OAT1 and OAT3 because of its high URAT1 selectivity.
The usual adult dosage is 0.5 mg of Dotinurad, administered orally once daily. After that, gradually increase the dose as necessary while checking the blood uric acid level. The maintenance dose is usually 2 mg once a day and the dose may be adjusted according to the patient's condition but the maximum dose should be 4 mg once a day.
Dotinurad is contraindicated in patients with known hypersensitivity to the drug component.
During pregnancy, Dotinurad should only be treated if the therapeutic benefits are judged to outweigh the risks. This drug is excreted in breast milk. Consult your doctor before breastfeeding.
Store below 30°C and dry place, away from light. Keep out of the reach of children.

Commonly reported side effects: gouty arthritis, limb discomfort
Less common side effects: loose stools, increased y-GTP, arthralgia, kidney stones, nephrocalcinosis, increased urinary y2 macroglobulin, increased blood creatinine, increased urine albumin/creatinine ratio, positive urine albumin