Xadu 100 mg (Tablet)
Unit Price: ৳ 600.00 (1 x 6: ৳ 3,600.00)
Strip Price: ৳ 3,600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adult patients
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis
- Increases endogenous production of erythropoietin
- Improves iron regulation
- Overcomes EPO-suppressive effects of inflammation
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Anti-anemic activity
- Binds to and inhibits HIF-PH
- Prevents HIF breakdown
- Promotes HIF activity
- Increases endogenous erythropoietin production
- Reduces expression of hepcidin
- Improves iron availability
- Boosts hemoglobin (Hb) levels
- Regulates genes in response to reduced oxygen levels
- Induces coordinated erythropoiesis
- Maintains plasma erythropoietin levels
- Reduces dysregulation of iron metabolism associated with CKD
- Reduces cholesterol levels
Dosage & Administration
- Orally administered three times per week
- Dose individualized to achieve and maintain target Hb levels of 10 to 12 g/dL
- Different starting doses for patients not on erythropoiesis-stimulating agent treatment and patients switching from erythropoiesis-stimulating agents
- Dose adjustments based on patient's condition
- Missed dose instructions provided
- Method of administration: tablets to be taken orally with or without food
Interaction
- Potential drug-drug interactions with phosphate binders, gemfibrozil, probenecid, OATP1B1, BCRP Substrates
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, nausea
Pregnancy & Lactation
- Contraindicated during pregnancy and breast-feeding
Precautions & Warnings
- Thrombotic vascular events (TVEs) caution
- Caution in patients with pre-existing risk factors for TVE
- Caution in patients with a history of seizures
- Not to be administered in patients with serious signs and symptoms of infection or liver disorder
Use in Special Populations
- Not indicated in children
- Not recommended for use in patients with severe hepatic impairment
Overdose Effects
- Symptoms of increased heart rate transient
- Likely increase in hemoglobin concentration
- Treatment involves appropriate dose reduction or interruption
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool (below 30°C), dry place
- Away from light and moisture
- Keep out of the reach of children