Vancin 1 gm/vial (IV Infusion)
1 gm vial: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vancomycin hydrochloride |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of life-threatening infections
- Therapy for severe staphylococcal infections
- Treatment of endocarditis
- Prophylaxis against endocarditis
- Effective in osteomyelitis, pneumonia, septicemia, and soft tissue infections
Pharmacology
- Binds tightly to D-alanyl-D-alanine portion of cell wall precursor
- Causes blockage of glycopeptide polymerization
- Inhibits cell wall synthesis
- Causes secondary damage to the cytoplasmic membrane
Dosage & Administration
- Concentration recommendation for adults
- Dosage adjustment for patients with impaired renal function
- Dosage adjustment for elderly patients
- Recommended dosage for antibiotic-associated pseudomembranous colitis
- Usual daily dose for adults and children
Contraindications
- Contraindicated in patients with known hypersensitivity to vancomycin
Side Effects
- Potential anaphylactic reactions
- Hypotension
- Wheezing
- Dyspnea
- Urticaria
- Pruritus
- Flushing of the upper body
- Pain and muscle spasm of the chest and back
Pregnancy & Lactation
- Unknown effect on fetal harm
- Caution in pregnancy
- Monitoring of blood levels in pregnancy
- Excretion in human milk
- Caution in nursing women
Precautions & Warnings
- Serial tests of auditory function for patients with borderline renal function and individuals over 60
- Periodic haematological studies
- Urine analysis and renal function tests
- Irritating to tissue, causing injection site necrosis if injected intramuscularly
- Injection site pain and thrombophlebitis
- Overgrowth of non-susceptible organisms with prolonged use
- Observation for superinfection during therapy
- Risk of pseudomembranous colitis due to C. difficile
Overdose Effects
- Supportive care advised
- Maintenance of glomerular filtration
- Poor removal from blood by haemodialysis or peritoneal dialysis
- Limited benefit of haemoperfusion with Amberlite resin XAD-4
Therapeutic Class
- Other antibiotic
Storage Conditions
- Cool and dry storage
- Protection from light
- Keep out of reach of children