Prelizer-AM 2.5 mg+5 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 14: ৳ 252.00)
Strip Price: ৳ 84.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Bisoprolol fumarate amlodipine besilate |
| Company | Radiant pharmaceuticals ltd |
Title
- Bisoprolol & Amlodipine Combination Tablet
Categories
- Medicine
- Pharmaceutical product
Description
- Treatment for hypertension
- Combination therapy for adequately controlled blood pressure
- Pharmacology consists of Amlodipine and Bisoprolol Fumarate
- Dosage: one tablet once daily for controlled blood pressure
- Caution in heart failure patients
- Not recommended for pregnant or lactating women
- Storage: Keep in a dry place below 30°C, protect from light
Dimensions
- Standard tablet size
Color Options
- Not applicable
Functions
- Controls blood pressure
- Inhibits transmembrane influx of calcium ions
- Reduces peripheral vascular resistance
Materials
- Amlodipine
- Bisoprolol Fumarate
- Excipients used in tablet formulation
Technical Specifications
- Beta1-selective adrenoceptor blocking agent
- Inhibits calcium ion influx across cell membranes
- Greater effect on vascular smooth muscle cells than on cardiac muscle cells
Design Elements
- Standard tablet shape and form
Usability Features
- Once daily dosage for convenience
- Caution in patients with impaired hepatic function
- Not recommended for patients with obstructive airways diseases
Interaction
- Combinations not recommended: Verapamil, diltiazem, centrally-acting antihypertensive drugs
- Combinations to be used with caution: Strong or moderate CYP3A4 inhibitors, simvastatin, Tacrolimus, Cyclosporine
- Combinations to be considered: Mefloquine, Rifampicin, Ergotamine derivatives, MAO inhibitors
Contraindications
- Acute heart failure
- Obstruction of the outflow tract of the left ventricle
- Cardiogenic shock
- Second or third degree AV block
- Sick sinus syndrome
- Severe bronchial asthma
- Untreated phaeochromocytoma
- Hypersensitivity to Bisoprolol, Amlodipine, or excipients
Side Effects
- Common: Dizziness, headache, somnolence, palpitations, edema, fatigue
- Uncommon: Insomnia, mood changes, visual disturbances, bradycardia, bronchospasm
- Rare: Allergic reactions, nightmares, hepatitis, increased triglycerides
Precautions & Warnings
- Caution in patients with heart failure or impaired hepatic function
- Avoid in patients with obstructive airways diseases
- Caution in patients with diabetes mellitus
- Gradual withdrawal advised before surgery
Use in Special Populations
- Geriatric use: Usual doses may be administered with caution in the elderly
- Pediatric use: Safety and efficacy not established for those below 18 years
- Patients with Liver disease: Caution in hepatic impairment, particularly severe cases
- Patients with Kidney disease: No dosage adjustment for mild to moderate renal impairment
Overdose Effects
- Signs of beta-blocker overdose: Bradycardia, hypotension, bronchospasm, hypoglycemia
- Signs of amlodipine overdose: Excessive peripheral vasodilation, systemic hypotension
Therapeutic Class
- Anti-hypertensive
Storage Conditions
- Keep in a dry place below 30°C, protect from light, keep out of reach of children