Xenap Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)

Strip Price: ৳ 150.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Astra biopharmaceuticals ltd

Relief of signs & symptoms of osteoarthritis
Relief of signs & symptoms of rheumatoid arthritis
Relief of signs & symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Naproxen is a NSAID with analgesic & antipyretic properties
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosage: one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage: based on weight, for naproxen/esomeprazole combination

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decreases the occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events compared to Naproxen alone
May be associated with a small increased risk of arterial thrombotic events
Oedema, hypertension, and cardiac failure have been reported in association with NSAID treatment

Should not be given during the first and second trimester of pregnancy unless the potential benefit to the patient outweighs the potential risk to the foetus
Contraindicated during the third trimester of pregnancy
Not recommended during breastfeeding
Use of NSAIDs like Naproxen may impair female fertility

The combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors to develop NSAID related gastro-intestinal complications include high age, concomitant use of anticoagulants, corticosteroids, other NSAIDs including low-dose acetylsalicylic acid, debilitating cardiovascular disease, Helicobacter pylori infection, and a history of gastric and/or duodenal ulcers and upper gastrointestinal bleeding

Adjustment of dosage may be required in elderly patients
Not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet

Symptoms include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, nausea, alterations in liver function, renal dysfunction, metabolic acidosis, and vomiting
No specific antidotes