Zoline 400 mg (Tablet)
Unit Price: ৳ 55.00 (1 x 10: ৳ 550.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linezolid |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Nosocomial pneumonia
- Community-acquired pneumonia
- Complicated skin and skin structure infection
- Uncomplicated skin and skin structure infections
- Vancomycin-resistant Enterococcus faecium infections
Pharmacology
- Synthetic antibacterial agent
- Oxazolidinones class of antibiotics
- Inhibition of bacterial protein synthesis
- Bacteriostatic against enterococci and staphylococci
- Bactericidal for majority of streptococci
Dosage & Administration
- Oral and intravenous route of administration
- Recommended daily dosage for different infections
- No dose adjustment needed for switch from IV to oral administration
- Special dosing considerations for neonates with lower systemic clearance
Interaction
- Reversible, nonselective inhibitor of monoamine oxidase
- Potential interaction with adrenergic and serotonergic agents
- Advice to avoid large quantities of foods with high tyramine content
Contraindications
- Hypersensitivity to Linezolid or any components
- Concurrent use of monoamine oxidase inhibitors
- Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis
- Contraindicated with certain sympathomimetic agents, vasopressive agents, dopaminergic agents, and serotonin re-uptake inhibitors
Side Effects
- Mild to moderate adverse events
- Common adverse events: diarrhea, headache, nausea
- Other adverse events: hypertension, dyspepsia, pruritus, tongue discoloration
Pregnancy & Lactation
- Potential benefit justifies potential risk in pregnancy
- Consideration of developmental and health benefits of breastfeeding
- Advising monitoring of breastfed infant for adverse effects
Precautions & Warnings
- Weekly monitoring of complete blood counts
- Prompt ophthalmic evaluation for visual impairment symptoms
- Not for catheter-related bloodstream infections or catheter-site infections
- Monitoring for potential increases in blood pressure
- Immediate medical evaluation for specific symptoms
Overdose Effects
- No reported cases of overdose
- Symptomatic and supportive care advised
- Approximately 30% removal during 3 hours of haemodialysis
Therapeutic Class
- Macrolides
Reconstitution
- Shaking and reconstitution of oral suspension
- Intravenous administration process
- Storage and usage guidelines for reconstituted suspension
Storage Conditions
- Room temperature storage
- Protection from light and moisture
- Keep away from children