Aleena 4 mg (Tablet)
(24 active+4 inert) tablets: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Drospirenone |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Progestin for oral contraceptive use in females
Pharmacology
- Drospirenone is a progestin for preventing pregnancy
- Lowers risk of pregnancy by suppressing ovulation
- Spironolactone analogue with anti-mineralocorticoid activity
Dosage & Administration
- Swallow one tablet daily for 28 consecutive days
- Take white active tablet daily for first 24 days and pink inert tablet for next 4 days
- Instructions for starting and switching
Absorption
- Dose-proportional pharmacokinetics
- Maximum plasma concentrations reached in 2-6 hours
- Concomitant food ingestion has no influence on absorption
Distribution
- 95% to 97% bound to serum albumin
- Apparent volume of distribution approximately 4 L/kg
Metabolism
- Extensively metabolized after oral administration
- Main metabolites identified in human plasma
- Subject to oxidative metabolism catalyzed by CYP3A4
Excretion
- Terminal disposition phase half-life approximately 30 hours
- Nearly complete excretion after ten days
- Slightly higher excretion in feces compared to urine
Interaction
- Effects of Other Drugs on Hormonal Contraceptives
- Substances Decreasing/Increasing Systemic Concentrations of Hormonal Contraceptives
- Potential to Increase Serum Potassium Concentration
Contraindications
- Renal impairment
- Adrenal insufficiency
- Progestin sensitive cancers
- Liver tumors or hepatic impairment
- Undiagnosed abnormal uterine bleeding
Side Effects
- Clinically significant Side Effects: Hyperkalemia, bleeding irregularities, and amenorrhea
- Other adverse reactions including acne, headache, nausea, decreased libido
Pregnancy & Lactation
- Little or no increased risk of birth defects during inadvertent use in early pregnancy
- Discontinue if pregnancy occurs
- Negligible amounts excreted in breast milk
- No adverse effects on infants' growth or development
Precautions & Warnings
- Hyperkalemia risk
- Thromboembolic Disorders
- Bone Loss
- Liver Disease
- Ectopic Pregnancy
- Risk of Hyperglycemia in Patients with Diabetes
- Bleeding Irregularities and Amenorrhea
- Depression
Overdose Effects
- No reports of serious deleterious effects
- Possible symptoms include nausea, vomiting, and vaginal bleeding
- No antidotes, treatment is symptomatic support
- Monitor serum potassium and sodium levels in case of overdose
Drug Classes
- Oral Contraceptive preparations
Storage Conditions
- Store below 30°C in a dry place
- Keep away from light and out of reach of children