Tripar 1 mg (Tablet)
Unit Price: ৳ 3.00 (4 x 14: ৳ 168.00)
Strip Price: ৳ 42.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders
- Treatment of postencephalitic and arteriosclerotic parkinsonism
Description
- Exerts direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Direct effect on muscle tissue
- Inhibitory effect on parasympathetic nervous system
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located central muscarinic receptors
Dosage & Administration
- Individualized dosage
- Low initial dose, gradually increased
- Dosing determined by patient's reaction
- Postencephalitic patients may require atropine adjuvant
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- Monoamine oxidase inhibitors and tricyclic antidepressants intensify anticholinergic effects
- Increased risk of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
- Blindness reported due to long-term use in narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Mild nausea
Pregnancy & Lactation
- Limited data on use during pregnancy
- Caution needed during lactation
- Potential to cause suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Potential for angle closure with anticholinergic drugs
- Caution in hot weather
Overdose Effects
- Central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium and seizures
- Treatment involves symptomatic and supportive therapy
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Store in a dry place
- Protect from light