Tripar 5 mg/5 ml (Syrup)
50 ml bottle: ৳ 125.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Title
- Tripar Antiparkinson Drug
Categories
- Medicine
- Antiparkinson
- Pharmaceutical
Dimensions
N/A
Color Options
- N/A
Functions
- Adjunct treatment of all forms of parkinsonism
- Control of extrapyramidal disorders caused by CNS drugs
- Exerts inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Materials
- Trihexyphenidyl
Technical Specifications
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity to M1 subtype receptors
- Higher affinity for central muscarinic receptors in cerebral cortex
Design Elements
- Tablet form
Usability Features
- Individualized dosage
- Low initial dose with gradual increase
- May be taken before or after meals
- Potential adjuvant therapy with levodopa
- Tolerated best if divided into 3 doses
- Dose adjustment required in concomitant use with levodopa or other parasympathetic inhibitors
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts direct inhibitory effect upon the parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Binds with higher affinity to the M1 subtype of muscarinic acetylcholine receptors
- Modifies nicotinic acetylcholine receptor neurotransmission
- Enhances dopamine release in the striatum
- Mechanism of action not fully elucidated
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Dose adjustment in concomitant use with levodopa or other parasympathetic inhibitors
- Best tolerated if divided into 3 doses
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia during concomitant administration with neuroleptics
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome with abrupt treatment withdrawal
Pregnancy & Lactation
- Not recommended during pregnancy unless need clearly established
- Caution advised during lactation due to potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Close monitoring of intraocular pressures
- Caution in hot weather and concomitant use with other atropine-like drugs
- Potential occurrence of anhidrosis and hyperthermia
- Potential occurrence of Neuroleptic Malignant Syndrome (NMS)
Overdose Effects
- Central symptoms of atropine intoxication
- Neuropsychiatric signs
- Hyperpyrexia, coma, cardiac and respiratory arrest
- Gastric lavage or methods to limit absorption recommended for acute overdose
Drug Classes
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light