Merocil 250 mg/vial (IV Injection or Infusion)

240 mg vial: ৳ 400.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Pharmacil limited
Also available as
Merocil 500 mg injection Merocil 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis, penetrates bacterial cell walls, stable to all serine beta-lactamases, shows potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria

Dosage

  • 500 mg to 1 gm by intravenous administration every 8 hours for adults
  • 10 to 40 mg/kg intravenously every 8 hours for children depending on type and severity of infection
  • Intra-abdominal infections: 20 mg/kg every 8 hours for children
  • Upto 2 gm every 8 hours for cystic fibrosis in adults
  • 2 gm IV every 8 hours for meningitis in adults

Administration

Intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

  • Probenecid competes with Merocil for active tubular secretion
  • Merocil may reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Careful monitoring of transaminase and bilirubin levels in patients with hepatic disease

Use in Special Populations

  • Dosage reduction in patients with creatinine clearance less than 51 ml/min
  • No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min

Overdose Effects

Treatment should be symptomatic. Rapid renal elimination will occur in normal individuals

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration
  • Intravenous infusion administration
  • Compatible with 0.9% sodium chloride intravenous infusion, 5% or 10% glucose intravenous infusion, and others

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light and moisture

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