X-Pro 20 mg (Capsule (Enteric Coated))

Title

• X-Pro 20 mg Capsule

Categories

• Medicine
• Health
• Gastroenterology

Description

• Proton pump inhibitor for relief from chronic heartburn and other symptoms associated with GERD, healing of erosive esophagitis, maintenance of healing of erosive esophagitis, eradication of Helicobacter pylori infection, treatment of Zollinger-Ellison Syndrome, acid-related Dyspepsia, and duodenal & gastric ulcer

Dimensions

• Standard tablet/capsule size

Color options

• None

Functions

• Reduces gastric acid secretion
• Aids in prevention and treatment of various stomach and esophagus-related conditions

Materials

• Contains esomeprazole magnesium in enteric-coated pellet formulation

Technical specifications

• Absorption: Peak plasma levels occur at approximately 1.5 hours
• Distribution: 97% bound to plasma proteins
• Metabolism: Extensively metabolized in the liver by the cytochrome P450 enzyme system
• Excretion: Plasma elimination half-life is approximately 1-1.5 hours

Design elements

• Enteric-coated pellet formulation
• Oral dosage form
• IV Injection or IV infusion

Usability features

• Swallow whole and take one hour before a meal for tablet/capsule
• Dosage form suitable for administration through nasogastric or gastric tube
• Solution for IV injection prepared by adding 0.9% Sodium Chloride

Concentration

• 20 mg or 40 mg

Indications

• Relief from chronic heartburn symptoms
• Healing of erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
• Treatment of Zollinger-Ellison Syndrome
• Treatment of acid-related Dyspepsia
• Treatment of duodenal & gastric ulcer

Dosage forms

• Oral capsule or tablet
• Oral suspension
• IV injection

Administration

• Swallow whole and take one hour before a meal for tablet/capsule
• Oral suspension: Mix and drink within 30 minutes; administer through nasogastric or gastric tube
• IV Injection: Administer intravenously over at least 3 minutes

Interaction

• Extensively metabolized in the liver by CYP2C19 and CYP3A4
• Inhibition of CYP2C19 may affect clearance of certain drugs
• Inhibition of gastric acid secretion may interfere with absorption of certain drugs

Contraindications

• Known hypersensitivity to any of the formulation

Side effects

• Headache
• Diarrhea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth

Pregnancy and lactation

• No adequate and well-controlled studies in pregnant women
• No teratogenic effects observed in animal studies
• Excretion in milk not studied; breastfeeding should be discontinued if essential

Precautions and warnings

• Symptomatic response does not preclude the presence of gastric malignancy
• Instructions for patients with difficulty swallowing capsules
• Use of antacids alongside X-Pro

Special populations

• No established safety and effectiveness in pediatric patients
• No overall differences in safety and efficacy observed between elderly and younger individuals
• No dosage adjustment recommended for mild to moderate hepatic insufficiency
• Pharmacokinetics not expected to be altered in renal impairment

Overdose effects

• High doses lethal to rats
• Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions
• No specific antidote known; treatment should be symptomatic and supportive

Storage conditions

• Store at a temperature not exceeding 30°C, protect from light and moisture, keep out of reach of children

Chemical structure

• Molecular Formula: C17H19N3O3S
• Chemical Structure: Image provided

Common questions

• Overview of X-Pro 20 mg Capsule
• Usage of X-Pro 20 mg Capsule
• Side effects of X-Pro 20 mg Capsule
• Considerations during pregnancy and breastfeeding
• Onset of action of X-Pro 20 mg Capsule
• Quick Tips for using X-Pro 20 mg Capsule

Related Brands

• S-Ome 20 mg (Tablet (Enteric Coated)) - somatec-pharmaceuticals-ltd
• S-Ome 40 mg (Tablet (Enteric Coated)) - somatec-pharmaceuticals-ltd
• Alton 20 mg (Tablet (Enteric Coated)) - general-pharmaceuticals-ltd
• Alton 40 mg (Tablet (Enteric Coated)) - general-pharmaceuticals-ltd
• Asector 20 mg (Capsule (Enteric Coated)) - novo-healthcare-and-pharma-ltd