Spilac-F 20 mg+50 mg (Tablet)

Title and Categories

• Spilac-F Tablet
• Diuretic Medication
• Potassium-Sparing Diuretic
• Aldosterone Antagonist
• Hypertension Medication
• Heart Failure Medication
• Liver Disease Medication
• Edema Medication

Dosage

• Furosemide 20 and spironolactone 50 mg
• Furosemide 40 and spironolactone 50 mg
• Adult Dosage: 1 to 4 tablets daily
• Use in children: Not suitable for use in children
• Elderly Patients: May be excreted more slowly in the elderly

Mode of Action

• Complementary mechanisms of spironolactone and furosemide
• Additive or synergistic diuretic effects
• Inhibits Na+/K+/2Cl- co-transporter
• Inhibits reabsorption of sodium and potassium
• Reduced potassium loss induced by furosemide

Indications

• Essential hypertension
• Chronic congestive heart failure
• Hepatic cirrhosis with ascites
• Swelling due to excess fluid retention (edema)
• Hyperaldosteronism
• Resistant edema with secondary hyperaldosteronism

Interaction

• Increased risk of hyperkalemia with ACE inhibitors or potassium salts
• Increased levels of cardiac glycosides like digoxin
• Possibility of digitalis toxicity
• Potential hypokalemia with corticosteroids
• Reduced diuretic effects when used with indomethacin or NSAIDs
• Increased ototoxicity with aminoglycoside antibiotics
• Reduction in natriuretic and anti-hypertensive effect with sucralfate

Contraindications

• Anuria
• Acute renal insufficiency
• Severe impairment of renal function
• Hyperkalemia
• Addison's disease
• Hypersensitivity to spironolactone, furosemide, or sulphonamides

Side Effects

• Headache
• Drowsiness
• Gastrointestinal distress
• Ataxia
• Mental confusion
• Skin rashes
• Gynaecomastia
• Breast enlargement
• Hirsutism
• Deepening of the voice
• Menstrual irregularities
• Impotence
• Transient increase in blood-urea-nitrogen concentrations
• Mild acidosis
• Hyponatremia
• Excessive diuresis leading to dehydration
• Reduction in blood volume with circulatory collapse
• Serious depletion of potassium and magnesium
• Cardiac arrhythmias

Pregnancy & Lactation

• Spironolactone and its metabolites may cross the placental barrier
• Use of furosemide in women of childbearing age should consider potential risks to the fetus
• Spironolactone metabolites detected in breast milk
• Discontinue breastfeeding if essential to use furosemide

Precautions & Warnings

• Caution in patients liable to electrolyte deficiency
• Use with caution in diabetes
• Use with caution in enlarged prostate
• Use with caution in hypotension
• Use with caution in hypovolemia

Therapeutic Class

• Potassium-sparing diuretics
• Aldosterone antagonists

Storage Conditions

• Keep below 30°C temperature
• Keep away from light & moisture
• Keep out of the reach of children

Related Brands

• Spilac-F 40 mg+50 mg (Tablet) - radiant-pharmaceuticals-ltd