Metorax 50 mg/2 ml (IV Injection or Infusion)
50 mg vial: ৳ 130.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Renata limited |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma
- Treatment of chorioadenoma destruens
- Treatment of hydatidiform mole
- Treatment of acute lymphoblastic leukemia
- Treatment of non-Hodgkin's lymphomas
- Management of severe, active rheumatoid arthritis
- Symptomatic control of severe, recalcitrant, disabling psoriasis
Pharmacology
- Inhibits dihydrofolic acid reductase
- Interferes with DNA synthesis, repair, and cellular replication
Dosage
- Orally or intramuscularly in doses of 15 to 30 mg daily for a five-day course
- Induction dose for acute lymphoblastic leukemia: 3.3 mg/m2 with prednisone
- Maintenance dose for acute lymphoblastic leukemia: 30 mg/m2 weekly
- Induction dose for lymphoma: 10 to 25 mg daily for 4 to 8 days
- Maintenance dose for mycosis fungoides: 5 to 50 mg once a week
Administration
- Best taken on an empty stomach
- May be taken with meals to reduce GI discomfort
- Avoid taking with milk-rich products
Interaction
- Should not be administered prior to or concomitantly with high doses of Metorax
- Toxicity may be increased by salicylates, phenylbutazone, phenytoin, and sulfonamides
- May increase the plasma levels of mercaptopurine
- May decrease intestinal absorption with tetracycline, chloramphenicol, and nonabsorbable antibiotics
Contraindications
- Alcoholism, alcoholic liver disease, or other chronic liver disease
- Immunodeficiency syndromes
- Hypersensitivity to methotrexate
- Pregnancy
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea and abdominal distress
- Malaise and undue fatigue
Pregnancy & Lactation
- US FDA Pregnancy Category X
- Contraindicated in nursing mothers
Precautions & Warnings
- Formulations and diluents with preservatives must not be used for therapy
- Follow patients closely for toxic effects
- Reduce dosage or discontinue if adverse reactions occur
- Persistent liver function test abnormalities
Use in Special Populations
- Benefits should be weighed against potential risk in pediatric patients
- Elderly patients should be closely monitored for toxicity
Overdose Effects
- Leucovorin is indicated to counteract the effect of overdosages
Therapeutic Class
- Antidote preparations
- Immunosuppressant
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light and moisture