Renolina M 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Dbl pharmaceuticals ltd |
| Also available as |
Usability and Instructions
- Adjunct to diet and exercise to improve glycemic control
- Dose should be individualized based on effectiveness and tolerability
- Maximum recommended dose of Linagliptin and Metformin Hydrochloride
- Different dosages for immediate release and extended release tablets
- Cautious dose escalation to reduce gastrointestinal side effects
- Temporary discontinuation before radiologic studies or surgical procedures
Technical Specifications
- Inhibitor of DPP-4 enzyme
- Increases concentrations of active incretin hormones
- Stimulates release of insulin from pancreatic beta cells
- Decreases secretion of glucagon from pancreatic alpha cells
- Lowers both basal and postprandial plasma glucose
- Improves insulin sensitivity by increasing peripheral glucose uptake
Interaction and Compatibility
- Potential interaction with cationic drugs
- Concomitant use with carbonic anhydrase inhibitors
- Interactions with inducers of P-glycoprotein and CYP3A4 enzymes
- Drugs affecting glycemic control
- Hypoglycemia more common when used with sulfonylureas
Contraindications
- Contraindicated in patients with renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects include nasopharyngitis and diarrhea
- Hypoglycemia more common with sulfonylureas
Pregnancy and Lactation
- Use during pregnancy only if clearly needed
- Caution when administered to a lactating mother
Precautions and Warnings
- Discontinue in case of lactic acidosis or suspected pancreatitis
- Monitor Vitamin B12 levels due to Metformin usage
- Symptoms and precautions related to lactic acidosis
- Instructions for alcohol consumption, other medicines, counseling, and travel
- Caution regarding hypoglycemia and its symptoms
Overdose Effects
- Usual supportive measures for overdose
- Unlikely removal of Linagliptin by dialysis, but Metformin is dialyzable
- No dose-related clinical adverse drug reactions with Linagliptin
- Reported hypoglycemia and lactic acidosis in Metformin overdose cases
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture