Renolina M 2.5 mg+850 mg (Tablet)
Unit Price: ৳ 14.00 (2 x 10: ৳ 280.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Dbl pharmaceuticals ltd |
| Also available as |
Product Title
- Renolina M Tablet
Categories
- Medication
- Healthcare
- Diabetes Management
Description
- An adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus
Dosage Form
- Immediate-release tablet
- Extended-release tablet
Active Ingredients
- Linagliptin
- Metformin Hydrochloride
Pharmacological Action
- Inhibition of DPP-4 enzyme
- Stimulation of insulin release
- Decrease in glucagon secretion
- Decrease in hepatic glucose production
- Improvement in insulin sensitivity
- Lowering of plasma glucose levels
Recommended Dosage
- Individualized based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects associated with Metformin Hydrochloride use
- Dose based on patient's current treatment with Metformin Hydrochloride or Linagliptin and Metformin Hydrochloride
Maximum Recommended Dose
- 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals for immediate release tablet
- 5 mg Linagliptin and 2000 mg Metformin Hydrochloride once daily with a meal for extended-release tablet
Cationic Drugs Interaction
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- Careful patient monitoring and dose adjustment recommended
Carbonic Anhydrase Inhibitors Interaction
- Use with caution due to risk of inducing metabolic acidosis
P-glycoprotein and CYP3A4 Enzymes Interaction
- Potential reduction in Linagliptin efficacy when co-administered with strong P-gp or CYP 3A4 inducers
Drugs Affecting Glycemic Control Interaction
- Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control when administered with Renolina M
Contraindications
- Renal impairment
- Acute or chronic metabolic acidosis
- Hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Nasopharyngitis
- Diarrhea
- Hypoglycemia
Pregnancy & Lactation
- Use only if clearly needed during pregnancy
- Caution during lactation
Precautions & Warnings
- Discontinue immediately in case of lactic acidosis or suspected pancreatitis
- Monitoring of hematologic parameters due to potential Vitamin B12 lowering effect
- Effects of alcohol, other medicines, counseling, travel, and emergencies
- Risk of hypoglycemia and its symptoms
Overdose Effects
- Supportive measures in event of overdose
- Hemodialysis or peritoneal dialysis unlikely for Linagliptin
- Metformin Hydrochloride is dialyzable
- No dose-related adverse reactions for Linagliptin up to 600 mg
- Hypoglycemia and lactic acidosis reported in Metformin Hydrochloride overdose cases
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of reach of children