Dementa XR 14 mg (Capsule (Extended Release))
Unit Price: ৳ 20.00 (4 x 8: ৳ 640.00)
Strip Price: ৳ 160.00
Medicine Details
Category | Details |
---|---|
Generic | Memantine hydrochloride |
Company | Ziska pharmaceuticals ltd |
Also available as |
Title
- Dementa XR
Categories
- Medicine
- Neurology
- Pharmacology
Description
- Treatment for all forms of dementia of the Alzheimer's type
- Indicated in other types of dementia
- Low to moderate affinity NMDA receptor antagonist
- Well absorbed after oral administration
- Excreted predominantly unchanged in urine
- Terminal elimination half-life of about 60-80 hours
- Highly absorbed with peak concentrations reached in about 3-7 hours
- Volume of distribution of 9-11 L/kg
- Low plasma protein binding (45%)
- Linear pharmacokinetics over the therapeutic dose range
- No effect of food on absorption
- Excreted as the sum of the parent drug and the N-glucuronide conjugate
- Partial hepatic metabolism
- No significant role of hepatic microsomal CYP-450 enzyme system in metabolism
- Recommended maintenance dose for adults and older patients is 20 mg/day
- Upward titration with 5 mg per week over 3 weeks to achieve maintenance dose
- Specific dosage guidelines for renal impairment
- Not recommended for use in children below 18 years
- Possible enhancement of effects of L-dopa, dopaminergic agonists, and anticholinergics
- Possible reduction in effects of barbiturates and neuroleptics
- Modification of effects of antispasmodic agents, dantrolene, or baclofen
- Contraindicated in patients with known hypersensitivity to Memantine Hydrochloride or excipients
- Side effects include hallucination, confusion, dizziness, headache, fatigue, anxiety, hypertonus, vomiting, bladder infections, increased sexual drive
- Potential increase in probability of epileptic seizures
- Pregnancy Category B
- Caution advised when administered to a nursing mother
- Caregivers should be instructed in the recommended administration and dose escalation
- Regular monitoring of kidney function for patients with kidney dysfunction
- No systematic evaluation in patients with a seizure disorder
- No risk of carcinogenesis, mutagenesis, or impairment of fertility
- Potential alteration of reaction time affecting safe driving and operation of machinery
- Storage in a cool and dry place
- Protection from light
- Keep out of reach of children