Dementa XR 14 mg (Capsule (Extended Release))

Unit Price: ৳ 20.00 (4 x 8: ৳ 640.00)
Strip Price: ৳ 160.00

Medicine Details

Title

  • Dementa XR

Categories

  • Medicine
  • Neurology
  • Pharmacology

Description

  • Treatment for all forms of dementia of the Alzheimer's type
  • Indicated in other types of dementia
  • Low to moderate affinity NMDA receptor antagonist
  • Well absorbed after oral administration
  • Excreted predominantly unchanged in urine
  • Terminal elimination half-life of about 60-80 hours
  • Highly absorbed with peak concentrations reached in about 3-7 hours
  • Volume of distribution of 9-11 L/kg
  • Low plasma protein binding (45%)
  • Linear pharmacokinetics over the therapeutic dose range
  • No effect of food on absorption
  • Excreted as the sum of the parent drug and the N-glucuronide conjugate
  • Partial hepatic metabolism
  • No significant role of hepatic microsomal CYP-450 enzyme system in metabolism
  • Recommended maintenance dose for adults and older patients is 20 mg/day
  • Upward titration with 5 mg per week over 3 weeks to achieve maintenance dose
  • Specific dosage guidelines for renal impairment
  • Not recommended for use in children below 18 years
  • Possible enhancement of effects of L-dopa, dopaminergic agonists, and anticholinergics
  • Possible reduction in effects of barbiturates and neuroleptics
  • Modification of effects of antispasmodic agents, dantrolene, or baclofen
  • Contraindicated in patients with known hypersensitivity to Memantine Hydrochloride or excipients
  • Side effects include hallucination, confusion, dizziness, headache, fatigue, anxiety, hypertonus, vomiting, bladder infections, increased sexual drive
  • Potential increase in probability of epileptic seizures
  • Pregnancy Category B
  • Caution advised when administered to a nursing mother
  • Caregivers should be instructed in the recommended administration and dose escalation
  • Regular monitoring of kidney function for patients with kidney dysfunction
  • No systematic evaluation in patients with a seizure disorder
  • No risk of carcinogenesis, mutagenesis, or impairment of fertility
  • Potential alteration of reaction time affecting safe driving and operation of machinery
  • Storage in a cool and dry place
  • Protection from light
  • Keep out of reach of children

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