M-K 10 mg (Tablet)

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Leukotriene receptor antagonist
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Correlated with the pathophysiology of asthma & allergic rhinitis

Dosage & Administration

• Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
• Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
• Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
• Dosage for pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily
• No dosage adjustment required in patients with mild-to-moderate hepatic insufficiency
• No dosage adjustment recommended in patients with renal insufficiency
• Elderly use: No dosage adjustment required

Interaction

• No clinically important effects on the pharmacokinetics of several drugs
• Used concomitantly with a wide range of commonly prescribed drugs
• Phenobarbital decreased the AUC of M-K approximately 40%

Contraindications

• Patients who are hypersensitive to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Can be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Should not be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking M-K

Overdose Effects

• Usual supportive measures should be employed in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S

Common Questions about M-K 10 mg Tablet

• Used to treat asthma or allergic rhinitis
• Helps keep airways open and easy breathing by blocking leukotrienes
• Effect can be observed after 1-3 hours of administration
• Lasts for an average duration of 24 hours
• May be taken with or without food as prescribed by doctor
• Use in pregnant women should be avoided unless clearly needed

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