Folistar 5 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists
- The treatment of megaloblastic anaemias
- Due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- Each tablet contains Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Each tablet contains Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium Folinate is the calcium salt of folinic acid
- Acts as a co-factor for 1-carbon transfer reactions
- Involved in the biosynthesis of purine and pyrimidines of nucleic acids
Dosage & Administration
- Calcium folinate rescue should begin as soon as possible after an inadvertent overdosage
- Dosage regimens vary depending upon the dose of methotrexate administered
Interactions
- Counteracts the antiepileptic effect of phenobarbitone, phenytoin and primidone
- Increases the frequency of seizures in susceptible patients when given with fluoropyrimidine
Contraindications
- Known hypersensitivity to calcium folinate or any other components of this product
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Should only be used in pregnant women if the potential benefit justifies the potential risk to the fetus
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Administered as soon as possible in the treatment of inadvertent overdosage of a folic acid antagonist
Overdose Effects
- Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
- There is no specific antidote to calcium folinate overdose
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children